Evidence map›Paper›PMID 29410359›Full record

ArticleNeuroscience letters2018

Modulation of the zebrafish optokinetic reflex by pharmacologic agents targeting GABA

Enhua Shao, Seth D Scheetz, Wenting Xie, Edward A Burton

Open access · bronzeAbstract read
In one paragraph

Article in Neuroscience letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Enhua ShaoPittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Tsinghua University Medical School, Beijing, China.
Seth D ScheetzPittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Wenting XiePittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Tsinghua University Medical School, Beijing, China.
Edward A BurtonPittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Geriatric Research, Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA. Electronic address: eab25@pitt.edu.
University of Pittsburgh · USTsinghua University · CNVA Pittsburgh Healthcare System · US

Funding

Development of Zebrafish Taupoathy Models for Translational ResearchR21NS080881 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BURTON, EDWARD ALAN · 2013 to 2014
$419k
Role of BET proteins in neuroinflammation in tauopathyI01BX003168 · VA · VETERANS HEALTH ADMINISTRATION · PI Edward Alan Burton · 2017 to 2026
–
BLRD VA I01 BX003168NINDS NIH HHS R21 NS080881
6 · The paper itself

Abstract

Optokinetic reflex (OKR) responses provide a convenient means to evaluate visual, integrative and oculomotor function in larval zebrafish. We measured multiple aspects of the OKR response in zebrafish exposed systemically to compounds altering signaling at GABA

Indexed as

AnimalsGABA-A Receptor AgonistsGABA-A Receptor AntagonistsIsoxazolesNystagmus, OptokineticPhotic StimulationPicrotoxinReflexSaccadesZebrafishGABA-A Receptor AgonistsGABA-A Receptor AntagonistsgaboxadolIsoxazolesPicrotoxinGABAGaboxadolOptokinetic reflexPicrotoxinZebrafish

Identifiers

PMID29410359
PMCPMC5889744
OpenAlexW2791948785

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.