ArticleClinical immunology (Orlando, Fla.)2018
Plasmablast antibody repertoires in elderly influenza vaccine responders exhibit restricted diversity but increased breadth of binding across influenza strains.
Article in Clinical immunology (Orlando, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Antiviral CD4Communications medicine · 2026Article
- Review
- Co-evolution of immunity and seasonal influenza viruses.Nature reviews. Microbiology · 2023Review
- A spatial sequencing atlas of age-induced changes in the lung during influenza infection.Nature communications · 2023Article
- Article
- Indoxyl Sulfate Alters the Humoral Response of the ChAdOx1 COVID-19 Vaccine in Hemodialysis Patients.Vaccines · 2022Article
- Decreased vaccine protection of egg-based influenza vaccine in the elderly and nonhemagglutinin-focused immunity.The Journal of clinical investigation · 2021Article
- Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans.The Journal of clinical investigation · 2021Article
- B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat.Viruses · 2021Review
- Aging and Options to Halt Declining Immunity to Virus Infections.Frontiers in immunology · 2021Review
- Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination.Immunity & ageing : I & A · 2020Review
- Review
- Influence of immune aging on vaccine responses.The Journal of allergy and clinical immunology · 2020Review
- Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.Cell host & microbe · 2019Article
- Immunosenescence and human vaccine immune responses.Immunity & ageing : I & A · 2019Review
- Immunogenicity And Safety Of The 13-Valent Pneumococcal Conjugate Vaccine In Patients With Monoclonal Gammopathy Of Undetermined Significance - Relationship With Selected Immune And Clinical Parameters.Clinical interventions in aging · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
Seasonal influenza vaccines elicit antibody responses that can prevent infection, but their efficacy is reduced in the elderly. While a subset of elderly individuals can still mount sufficient vaccine-induced antibody responses, little is known about the properties of the vaccine-induced antibody repertoires in elderly as compared to young responders. To gain insights into the effects of aging on influenza vaccine-induced antibody responses, we used flow cytometry and a cell-barcoding method to sequence antibody heavy and light chain gene pairs expressed by individual blood plasmablasts generated in response to influenza vaccination in elderly (aged 70-89) and young (aged 20-29) responders. We found similar blood plasmablast levels in the elderly and young responders seven days post vaccination. Informatics analysis revealed increased clonality, but similar heavy chain V(D)J gene usage in the elderly as compared to young vaccine responders. Although the elderly responders exhibited decreased antibody sequence diversity and fewer consequential mutations relative to young responders, recombinant antibodies from elderly responders bound a broader range of influenza strain HAs. Thus elderly influenza vaccine responders mount plasmablast responses with restricted diversity but with an increased breadth of binding across influenza strains. Our results suggest that the ability to generate plasmablast responses encoding cross-strain binding antibodies likely represents a mechanism important to vaccine responses in the elderly.
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Registered trials
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