ArticleMetabolism: clinical and experimental2018
Use of BMI as the marker of adiposity in a metabolic syndrome severity score: Derivation and validation in predicting long-term disease outcomes.
Article in Metabolism: clinical and experimental, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 63 citations in OpenAlex.
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- Associations of Sleep Health and Metabolic Syndrome Severity in Black Individuals: The Jackson Heart Sleep Study.The Journal of clinical endocrinology and metabolism · 2025Article
- MetS-Z: A gender- and age-specific scoring system for predicting type 2 diabetes.Journal of diabetes investigation · 2025Article
- Comparison of the predictive value of 17 anthropometric in-dices for the prevalence of metabolic syndrome among Chinese residents: a cross-sectional study.Diabetology & metabolic syndrome · 2025Article
- Metabolic dysfunction and incidence of heart failure subtypes among Black individuals: The Jackson Heart Study.European journal of heart failure · 2025Article
- The association between inflammatory markers, walking speed, and metabolic syndrome in older Chinese adults.Aging clinical and experimental research · 2025Article
- Relationship between body roundness index and mortality rates and life expectancy in populations with metabolic syndrome.Frontiers in cardiovascular medicine · 2025Article
- Identifying Four Developmental Trajectories of Metabolic Syndrome and Their Influencing Factors: A Longitudinal Cohort Study of Railway Employees' Physical Examinations.International journal of endocrinology · 2025Article
- Metabolic Syndrome Is Associated With Poor Prognosis in Patients With Breast Cancer Receiving Neoadjuvant Therapy.Cancer medicine · 2024Article
- Exploratory analysis of the variable response to an intensive lifestyle change program for metabolic syndrome.BMC primary care · 2024Article
- Effects of Metabolic Syndrome on Pregnancy Outcomes in Women Without Polycystic Ovary Syndrome.Journal of the Endocrine Society · 2024Article
- Gender-Affirming Hormone Treatment and Metabolic Syndrome Among Transgender Veterans.JAMA network open · 2024Article
- Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2024Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEstimates of adiposity in evaluating the metabolic syndrome (MetS) have traditionally utilized measures of waist circumference (WC), whereas body mass index (BMI) is more commonly used clinically. Our objective was to determine if a MetS severity Z-score employing BMI as its measure of adiposity (MetS-Z-BMI) would perform similarly to a WC-based score (MetS-Z-WC) in predicting future disease.
methodsTo formulate the MetS-Z-BMI, we performed confirmatory factor analysis on a sex- and race/ethnicity-specific basis on MetS-related data for 6870 adult participants of the National Health and Nutrition Survey 1999-2010. We then validated this score and compared it to MetS-Z-WC in assessing correlations with future coronary heart disease (CHD) and Type 2 diabetes mellitus (T2DM) using Cox proportional hazard analysis of 13,094 participants of the Atherosclerosis Risk in Communities study and Jackson Heart Study.
resultsLoading factors, which represent the relative contribution of each component to the latent MetS factor, were lower for BMI than for WC in formulating the two respective scores (MetS-Z-BMI and MetS-Z-WC). Nevertheless, MetS-Z-BMI and MetS-Z-WC exhibited similar hazard ratios (HR) toward future disease. For each one standard-deviation-unit increase in MetS-Z-BMI, HR for CHD was 1.76 (95% confidence interval [CI]: 1.65, 1.88) and HR for T2DM was 3.39 (CI 3.16, 3.63) (both p < 0.0001). There were no meaningful differences between the MetS-Z-WC and MetS-Z-BMI scores in their associations with future CHD and T2DM.
conclusionsA MetS severity Z-score utilizing BMI as its measure of adiposity operated similarly to a WC-based score in predicting future CHD and T2DM, suggesting overall similarity in MetS-based risk as estimated by both measures of adiposity. This indicates potential clinical usefulness of MetS-Z-BMI in assessing and following MetS-related risk over time.
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