ReviewAdvanced drug delivery reviews
Fluorescence anisotropy imaging in drug discovery.
Review in Advanced drug delivery reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Room-Temperature Luminescence of Eosin Y and Phloxine B in Red- to Near-Infrared Optical Region.Journal of fluorescence · 2026Article
- Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research.Journal of the American Chemical Society · 2025Article
- Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms.Acta pharmaceutica Sinica. B · 2024Review
- The use of NADH anisotropy to investigate mitochondrial cristae alignment.Scientific reports · 2024Article
- Mannose-Coated Reconstituted Lipoprotein Nanoparticles for the Targeting of Tumor-Associated Macrophages: Optimization, Characterization, and In Vitro Evaluation of Effectiveness.Pharmaceutics · 2023Article
- Sequential Two-Photon Delayed Fluorescence Anisotropy for Macromolecular Size Determination.The journal of physical chemistry. B · 2023Article
- Imaging the rotational mobility of carbon dot-gold nanoparticle conjugates using frequency domain wide-field time-resolved fluorescence anisotropy.Journal of biomedical optics · 2023Article
- Effects of Cascading Optical Processes: Part I: Impacts on Quantification of Sample Scattering Extinction, Intensity, and Depolarization.Analytical chemistry · 2023Article
- Fullerenol Quantum Dots-Based Highly Sensitive Fluorescence Aptasensor for Patulin in Apple Juice.Toxins · 2022Article
- Plasmonic Amyloid Tactoids.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Development of Integrated Systems for On-Site Infection Detection.Accounts of chemical research · 2021Review
- Bright and stable luminescent probes for target engagement profiling in live cells.Nature chemical biology · 2021Article
- Fluorescence Anisotropy as a Temperature-Sensing Molecular Probe Using Fluorescein.Micromachines · 2021Article
- Two-Photon Fluorescence Imaging.Advances in experimental medicine and biology · 2021Article
- Functional nucleic acid-based fluorescence polarization/anisotropy biosensors for detection of biomarkers.Analytical and bioanalytical chemistry · 2020Review
- Extended dynamic range imaging for noise mitigation in fluorescence anisotropy imaging.Journal of biomedical optics · 2020Article
- Creating and screening natural product libraries.Natural product reports · 2020Review
- Fluorescence Anisotropy Sensor Comprising a Dual Hollow-Core Antiresonant Fiber Polarization Beam Splitter.Sensors (Basel, Switzerland) · 2020Article
- Improving nanotherapy delivery and action through image-guided systems pharmacology.Theranostics · 2020Review
- Near-Infrared-II Molecular Dyes for Cancer Imaging and Surgery.Advanced materials (Deerfield Beach, Fla.) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Non-invasive measurement of drug-target engagement can provide critical insights in the molecular pharmacology of small molecule drugs. Fluorescence polarization/fluorescence anisotropy measurements are commonly employed in protein/cell screening assays. However, the expansion of such measurements to the in vivo setting has proven difficult until recently. With the advent of high-resolution fluorescence anisotropy microscopy it is now possible to perform kinetic measurements of intracellular drug distribution and target engagement in commonly used mouse models. In this review we discuss the background, current advances and future perspectives in intravital fluorescence anisotropy measurements to derive pharmacokinetic and pharmacodynamic measurements in single cells and whole organs.
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Registered trials
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