Trial reportProgress in neuro-psychopharmacology & biological psychiatry2018
The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram.
Trial report in Progress in neuro-psychopharmacology & biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Structural and functional features of treatment-resistant depression: A systematic review and exploratory coordinate-based meta-analysis of neuroimaging studies.Psychiatry and clinical neurosciences · 2023Pooled it
- Meta-analysis of cortical thickness abnormalities in medication-free patients with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Pooled it
- Prefrontal Transcranial Pulse Stimulation for Major Depressive Disorder: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: Evidence from a multimodal neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- One-week escitalopram intake alters the excitation-inhibition balance in the healthy female brain.Human brain mapping · 2022Trial
- Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake.Scientific reports · 2021Trial
- Differences in cortical gyrification and fractional amplitude of low-frequency fluctuations between early- and late-onset obsessive-compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2026Article
- Changes in Neural Activities and Neuroplasticity Related to Nonpharmacological Interventions for Major Depressive Disorder: A Systematic Literature Review.Biological psychiatry global open science · 2025Review
- Chronic pain is linked to a resting-state neural archetype that optimizes learning from punishments.bioRxiv : the preprint server for biology · 2025Article
- Pharmacological manipulation of neurotransmitter activity induces disparate effects on cerebral blood flow and resting-state fluctuations.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Altered dynamic functional network connectivity in drug-naïve Parkinson's disease patients with excessive daytime sleepiness.Frontiers in aging neuroscience · 2023Article
- Alterations of Power Spectral Density in Salience Network during Thought-action Fusion Induction Paradigm in Obsessive-compulsive Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- Effects of an Oral Contraceptive on Dynamic Brain States and Network Modularity in a Serial Single-Subject Study.Frontiers in neuroscience · 2022Article
- Behavioral, cortical and autonomic effects of single-dose escitalopram on the induction and regulation of fear and disgust: Comparison with single-session psychological emotion regulation with reappraisal.Frontiers in psychiatry · 2022Article
- Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder.Translational psychiatry · 2021Article
- Altered Dynamic Functional Connectivity inFrontiers in aging neuroscience · 2021Article
- Brain Networks Connectivity in Mild to Moderate Depression: Resting State fMRI Study with Implications to Nonpharmacological Treatment.Neural plasticity · 2021Article
- SSRI Treatment Response Prediction in Depression Based on Brain Activation by Emotional Stimuli.Frontiers in psychiatry · 2020Article
- Predicting Antidepressant Citalopram Treatment Response via Changes in Brain Functional Connectivity After Acute Intravenous Challenge.Frontiers in computational neuroscience · 2020Article
- Triple Network Model Dynamically Revisited: Lower Salience Network State Switching in Pre-psychosis.Frontiers in physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundStatic and dynamic functional connectivity are being increasingly used to measure the effects of disease and a range of different interventions on brain networks. While preliminary evidence suggests that static connectivity can be modulated by chronic antidepressants administration in healthy individuals and in major depression, much less is known about the acute effects of antidepressants especially on dynamic functional connectivity changes. Here we examine acute effects of antidepressants on dynamic functional connectivity within the default mode network. The default mode network is a well described network with many functions in which the role of serotonin is not clear.
methodsIn this work we measured acute pharmacological effects of an infusion of the selective serotonin reuptake inhibitor (SSRI) citalopram (10 mg) in a sample of thirteen healthy volunteers randomised to receive on two occasions the active compound or placebo in a cross over dosing.
resultsAcute citalopram administration relative to placebo increased static connectivity between the medial prefrontal cortex and right dorsolateral prefrontal cortex and posterior cingulate cortex. The SSRI also induced a reduction in variability of connectivity with the medial prefrontal cortex in the precuneus and posterior cingulate cortex. DISCUSSION: The measured changes are compatible with modified serotonin cortical availability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.