ArticlePharmacology, biochemistry, and behavior2018
Locomotor activity does not predict individual differences in morphine self-administration in rats.
Article in Pharmacology, biochemistry, and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Preclinical abuse potential testing using behavioral economics and drug self-administration demand-curve analysis: A strategy to improve resolution of drug stratification for regulatory control.Pharmacological reviews · 2026Review
- An examination of the interaction between the interoceptive and reinforcing properties of morphine: a self-administration study in male and female rats.Psychopharmacology · 2026Article
- Incentive Salience, not Psychomotor Sensitization or Tolerance, Drives Escalation of Cocaine Self-Administration in Heterogeneous Stock Rats.bioRxiv : the preprint server for biology · 2025Article
- Validation of drug-nondrug choice procedure to model maladaptive behavioural allocation to opioid use in rats.Addiction biology · 2024Article
- Magnitude and predictors of elasticity of demand for morphine are similar in male and female rats.Frontiers in behavioral neuroscience · 2024Article
- The effects of sleep restriction during abstinence on oxycodone seeking: Sex-dependent moderating effects of behavioral and hypothalamic-pituitary-adrenal axis-related phenotypes.Physiology & behavior · 2023Article
- Novelty-induced locomotor behavior predicts heroin addiction vulnerability in male, but not female, rats.Psychopharmacology · 2022Article
- The sensation seeking trait confers a dormant susceptibility to addiction that is revealed by intermittent cocaine self-administration in rats.Neuropharmacology · 2021Article
- Behavioral predictors of individual differences in opioid addiction vulnerability as measured using i.v. self-administration in rats.Drug and alcohol dependence · 2021Review
- Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Individual Differences in Different Measures of Opioid Self-Administration in Rats Are Accounted for by a Single Latent Variable.Frontiers in psychiatry · 2021Article
- Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats.Psychopharmacology · 2020Article
- Molecular Adaptations in the Rat Dorsal Striatum and Hippocampus Following Abstinence-Induced Incubation of Drug Seeking After Escalated Oxycodone Self-Administration.Molecular neurobiology · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Understanding factors contributing to individual differences in opioid addiction vulnerability is essential for developing more effective preventions and treatments. Sensation seeking has been implicated in addiction to several drugs of abuse, yet its relationship with individual differences in opioid addiction vulnerability has not been well established. The primary goal of this study was to evaluate the relationship between locomotor activity in a novel environment, a preclinical model of sensation-seeking, and individual differences in acquisition of i.v. morphine self-administration (SA) in rats. A secondary goal was to evaluate the relationship between activity and elasticity of demand (reinforcing efficacy) for morphine measured using a behavioral economic approach. Following an initial locomotor activity screen, animals were allowed to acquire morphine SA at a unit dose of 0.5 mg/kg/infusion in 4 hour/day sessions (Experiment 1) or 0.2 mg/kg/infusion in 2 hour/day sessions (Experiment 2) until infusion rates were stable. Unit price was subsequently manipulated via progressive reductions in unit dose (Experiment 1) or increases in response requirement per infusion (Experiment 2). Activity levels were not correlated with acquisition of morphine SA in either experiment. Morphine consumption was generally well described by an exponential demand function in both experiments (R
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.