Evidence map›Paper›PMID 29409733›Full record

ArticleJournal of the Academy of Nutrition and Dietetics2018

Nutrition and Bone Density in Boys with Autism Spectrum Disorder.

Ann M Neumeyer, Natalia Cano Sokoloff, Erin I McDonnell, Eric A Macklin, Christopher J McDougle, Tara M Holmes, Jane L Hubbard, Madhusmita Misra

Open access · greenAbstract read
In one paragraph

Article in Journal of the Academy of Nutrition and Dietetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Bone health in children and youth with ASD: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
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  17. Bone Health in Childhood Chronic Disease.Endocrinology and metabolism clinics of North America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ann M Neumeyer
Natalia Cano Sokoloff
Erin I McDonnell
Eric A Macklin
Christopher J McDougle
Tara M Holmes
Jane L Hubbard
Madhusmita Misra

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUKL2TR000102 · NCATS · GEORGETOWN UNIVERSITY · PI MELLMAN, THOMAS A, VERBALIS, JOSEPH G · 2012 to 2014
$1.7M
Bone Metabolism and Body Composition in Young AthletesK24HD071843 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2013 to 2017
$930k
NCATS NIH HHS KL2 TR000102NCRR NIH HHS UL1 RR025758NICHD NIH HHS K24 HD071843
6 · The paper itself

Abstract

backgroundBoys with autism spectrum disorder (ASD) have lower bone mineral density (BMD) than typically developing controls. Differences in diet and exercise may contribute to low BMD.

objectiveOur aim was to examine macro- and micronutrient intakes and self-reported physical activity in boys with ASD compared to TDC and the relationship of these variables with BMD. DESIGN/

methodsWe conducted a cross-sectional study of 49 boys (25 ASD, 24 typically developing controls) assessed for 3-day food records and physical activity records, and BMD of the whole body less head, hip, and spine using dual-energy x-ray absorptiometry. Fasting levels of 25(OH) vitamin D and calcium were obtained.

participantsParticipants were adolescent boys, aged 8 to 17 years, recruited from a clinic population (ASD) or community advertisements (ASD and typically developing controls) matched for age.

resultsASD participants were approximately 9 months younger than typically developing control participants on average. Body mass index and serum vitamin D and calcium levels were similar. Boys with ASD consumed 16% fewer calories, with a larger percentage obtained from carbohydrates, and 37% less animal protein and 20% less fat than typically developing controls. A lower proportion of ASD participants were categorized as "very physically active" (27% vs 79%; P<0.001). BMD z scores were 0.7 to 1.2 standard deviations lower in ASD than typically developing controls at all locations. Higher animal protein, calcium, and phosphorus intakes were associated positively with bone density measures in boys with ASD.

conclusionsCompared to typically developing controls, boys with ASD had lower protein, calcium, and phosphorus intakes, activity levels, and BMD z scores at the lumbar spine, femoral neck, total hip, and whole body less head. Protein, calcium, and phosphorus intakes were associated positively with BMD.

Indexed as

Bone DensityNutritional StatusAbsorptiometry, PhotonAdolescentAutism Spectrum DisorderCalciumCase-Control StudiesChildCross-Sectional StudiesDietDiet SurveysFastingHumansMaleVitamin D25-hydroxyvitamin DCalciumVitamin DAutism spectrum disorderBone mineral densityNutrient intakePhysical activity

Identifiers

PMID29409733
PMCPMC5924619
OpenAlexW2785895205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.