ArticleOphthalmology2018
The DISCOVER Study 3-Year Results: Feasibility and Usefulness of Microscope-Integrated Intraoperative OCT during Ophthalmic Surgery.
Article in Ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05790408 (Anterior-segment OCT), which is not on this map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anterior-segment OCT (AS-OCT) and Intraoperative OCT (iOCT) for Trans- Conjunctival Needle Revision (TCNR) of Trabeculectomy Bleb
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Synthesis of the clinical utilities and issues of intraoperative imaging devices in clinical reports: a systematic review and thematic synthesis.BMC medical informatics and decision making · 2025Pooled it
- Clinical applications for intraoperative optical coherence tomography: a systematic review.Eye (London, England) · 2022Pooled it
- COMPARE COMBINED USE OF ANTI-VEGF DRUGS DURING OR AFTER PARS PLANA VITRECTOMY FOR DIABETIC MACULAR EDEMA GUIDED BY MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY.Retina (Philadelphia, Pa.) · 2026Trial
- Multicolor Scanning Laser Ophthalmoscopy Strengthens Surgeons' Preoperative Decision-Making and Intraoperative Performance on Epiretinal Membrane.Translational vision science & technology · 2020Trial
- Surgery for epiretinal membrane using three different surgical platforms: A comparative pilot study.Romanian journal of ophthalmologyTrial
- Chromovitrectomy: current evidence, emerging technologies, and practical applications in vitreoretinal surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- [Real-time OCT-guided strategies for optimization of precision and safety in vitreoretinal surgery].Die Ophthalmologie · 2026Review
- Application of digital surgery in ophthalmology: intraoperative display of pre-operative enface OCT and ERM peeling unveiling the role of ERM adherence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Feasibility of Intraoperative SS-OCT for Assessing Capsular-Bag Dynamics During Cataract Surgery: Pilot Randomized Intra-Individual Comparison of Adaptive Versus Gravity-Based Fluidics.Diagnostics (Basel, Switzerland) · 2026Article
- Real-Time High-Resolution OCT for Imaging Retinal and Choroidal Blood Flow.Investigative ophthalmology & visual science · 2026Article
- A discrepancy in epiretinal proliferation detection between preoperative OCT and intraoperative observation in macular hole.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Swept-source intraoperative optical coherence tomography for real-time detection of anterior segment membranes during cataract surgery: a case series.Quantitative imaging in medicine and surgery · 2026Article
- Inverted internal limiting membrane flap technique versus internal limiting membrane removal in large macular hole with different hole edge configurations: a comparative study.Frontiers in medicine · 2026Article
- Cost reduction and quality preservation with digital scanner interfaces for optical coherence tomography.Journal of biomedical optics · 2025Article
- The efficacy of intraoperative OCT combined with foldable artificial vitreous balloon (FCVB) implantation in eyes with complex retinal detachment and silicone oil dependence.BMC ophthalmology · 2025Article
- The impact of intraoperative optical coherence tomography on cognitive load in virtual reality vitreoretinal surgery training.Scientific reports · 2025Article
- Intraoperative Spectrally Encoded Coherence Tomography and Reflectometry (iSECTR) for Ophthalmic Surgical Guidance.Translational vision science & technology · 2025Article
- The Feasibility and Clinical Evaluation of an Immersive Augmented Reality Surgical Headset Integrated with Swept-Source Intraoperative Optical Coherence Tomography for Ophthalmic Surgery in the DISCOVER Study.Diagnostics (Basel, Switzerland) · 2025Article
- A review of rhegmatogenous retinal detachment: past, present and future.Wiener medizinische Wochenschrift (1946) · 2025Review
- SpecstatOR: speckle statistics-based iOCT segmentation network for ophthalmic surgery.Biomedical optics express · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
purposeTo report the 3-year assessment of feasibility and usefulness of microscope-integrated intraoperative OCT (iOCT) during ophthalmic surgery.
designProspective, consecutive case series.
participantsAdult participants undergoing incisional ophthalmic surgery with iOCT imaging who consented to be enrolled in the Determination of Feasibility of Intraoperative Spectral-Domain Microscope Combined/Integrated OCT Visualization during En Face Retinal and Ophthalmic Surgery (DISCOVER) study.
methodsThe DISCOVER study is a single-site, multisurgeon, institutional review board-approved investigational device prospective study. Participants included patients undergoing anterior or posterior segment surgery who underwent iOCT imaging with 1 of 3 prototype microscope-integrated iOCT systems (i.e., Zeiss Rescan 700, Leica EnFocus, or Cole Eye iOCT systems). Clinical characteristics were documented, iOCT was directed by the operating surgeon at predetermined surgical time points, and each surgeon completed a questionnaire after surgery to evaluate the usefulness of iOCT during surgery.
main outcome measuresFeasibility of iOCT based ability to obtain an OCT image during surgery and usefulness of iOCT based on surgeon reporting during surgery.
resultsEight hundred thirty-seven eyes (244 anterior segment cases and 593 posterior segment cases) were enrolled in the DISCOVER study. Intraoperative OCT demonstrated feasibility with successful image acquisition in 820 eyes (98.0%; 95% confidence interval [CI], 96.8%-98.8%). In 106 anterior segment cases (43.4%; 95% CI, 37.1%-49.9%), the surgeons indicated that the iOCT information impacted their surgical decision making and altered the procedure. In posterior segment procedures, surgeons reported that iOCT enabled altered surgical decision making during the procedure in 173 cases (29.2%; 95% CI, 25.5%-33.0%).
conclusionsThe DISCOVER iOCT study demonstrated both generalized feasibility and usefulness based on the surgeon-reported impact on surgical decision making. This large-scale study confirmed similar findings from other studies on the potential value and impact of iOCT on ophthalmic surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.