Evidence map›Paper›PMID 29409377›Full record

ArticlePharmaceutical biology2018

The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet.

Natasa Bogavac-Stanojevic, Jelena Kotur Stevuljevic, Darko Cerne, Janja Zupan, Janja Marc, Zorica Vujic, Milkica Crevar-Sakac, Miron Sopic, Jelena Munjas, Miroslav Radenkovic and 1 more

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Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Bioactive Compounds from Artichoke and Application Potential.Food technology and biotechnology · 2023
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Natasa Bogavac-Stanojevica Department of Medical Biochemistry, Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
Jelena Kotur Stevuljevica Department of Medical Biochemistry, Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
Darko Cerneb Department of Clinical Chemistry, Faculty of Pharmacy , University of Ljubljana , Ljubljana , Slovenia.
Janja Zupanb Department of Clinical Chemistry, Faculty of Pharmacy , University of Ljubljana , Ljubljana , Slovenia.
Janja Marcb Department of Clinical Chemistry, Faculty of Pharmacy , University of Ljubljana , Ljubljana , Slovenia.
Zorica Vujicc Department of Pharmaceutical Chemistry, Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
Milkica Crevar-Sakacc Department of Pharmaceutical Chemistry, Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
Miron Sopica Department of Medical Biochemistry, Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
Jelena Munjasa Department of Medical Biochemistry, Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
Miroslav Radenkovicd Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine , University of Belgrade , Belgrade , Serbia.
Zorana Jelic-Ivanovica Department of Medical Biochemistry, Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextPolyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage.

objectivesWe examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta [haemeoxygenase-1 (HO1), haemeoxygenase-2 (HO2), NADPH oxidase 4 (NOX-4), monocyte chemoattractant protein-1 (MCP-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)]. MATERIALS AND

methodsEighteen male Wistar albino rats were divided into three groups (n = 6/group): The control group (CG) was fed with standard pellet chow for 11 weeks; the AD group was fed for a similar period of time with pellet chow supplemented with 2% cholesterol, 3% sunflower oil and 1% sodium cholate. The ADA group was fed with pellet chow (for 1 week), the atherogenic diet (see above) for the following 4 weeks and then with ALT (0.1 mL/kg body weight) and atherogenic diet for 6 weeks. According to HPLC analysis, the isolated main compounds in ALT were chlorogenic acid, caffeic acid, isoquercitrin and rutin.

resultsNormalized HO-1 [0.11 (0.04-0.24)] and MCP-1 [0.29 (0.21-0.47)] mRNA levels and DNA scores [12.50 (4.50-36.50)] were significantly lower in the ADA group than in the AD group [0.84 (0.35-2.51)], p = 0.021 for HO-1 [0.85 (0.61-3.45)], p = 0.047 for MCP-1 and [176.5 (66.50-221.25)], p = 0.020 for DNA scores. HO-1 mRNA was lower in the ADA group than in the CG group [0.30 (0.21-0.71), p = 0.049].

conclusionsSupplementation with ALT limited the effects of the atherogenic diet through reduced MCP-1 expression, thereby preventing oxidative damage.

Indexed as

Cynara scolymusPlant LeavesAnimalsAtherosclerosisDiet, AtherogenicDNA DamageMalePlant ExtractsRatsRats, WistarPlant Extractsgene expressionhaemeoxygenase-1monocyte chemoattractant protein-1Oxidative damage

Identifiers

PMID29409377
PMCPMC6130604

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.