Evidence map›Paper›PMID 29409142›Full record

ArticleArthritis care & research2018

Baseline Retinal Examinations in Patients With Systemic Lupus Erythematosus Newly Initiating Hydroxychloroquine Treatment in a US Medicaid Systemic Lupus Erythematosus Population, 2000-2010.

Tzu-Chieh Lin, Michael F Marmor, Medha Barbhaiya, Hongshu Guan, Sarah K Chen, Candace H Feldman, Karen H Costenbader

Abstract read
In one paragraph

Article in Arthritis care & research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tzu-Chieh LinBrigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-8333-7666
Michael F MarmorStanford University, Stanford, California.
Medha BarbhaiyaBrigham and Women's Hospital, Boston, Massachusetts.
Hongshu GuanBrigham and Women's Hospital, Boston, Massachusetts.
Sarah K ChenBrigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-8206-597X
Candace H FeldmanBrigham and Women's Hospital, Boston, Massachusetts.
Karen H CostenbaderBrigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-8972-9388
Brigham and Women's Hospital · USStanford University · US

Funding

Sociodemographic Disparities in SLE Incidence: Behavioral and Psychosocial FactorsR01AR057327 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI COSTENBADER, KAREN H · 2009 to 2019
$6.2M
Cardiovascular Disease Epidemiology in Patients with LupusK24AR066109 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI COSTENBADER, KAREN H · 2014 to 2023
$1.7M
Avoidable Acute Care Use among Patients with LupusK23AR071500 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI FELDMAN, CANDACE HILLARY · 2017 to 2021
$945k
NIAMS NIH HHS K23 AR071500NIAMS NIH HHS K24 AR066109NIAMS NIH HHS R01 AR057327
6 · The paper itself

Abstract

objectiveBaseline retinal examinations have long been recommended for patients beginning treatment with hydroxychloroquine (HCQ), but it is unknown how well this guideline is followed. We investigated baseline eye examinations among US SLE patients enrolled in Medicaid in whom HCQ treatment was newly initiated.

methodsUsing billing codes, we identified SLE patients ages 18-65 years who were enrolled in Medicaid and residing in the 29 most populated US states, from 2000 to 2010. New users of HCQ were identified by filled prescriptions, with none filled in the preceding 12 months. Retinal examinations that were performed within 30 days before to 1 year after the index prescription were identified. We examined the proportions of patients receiving retinal examinations over the study years and compared the characteristics of those who did and those who did not receive examinations, using bivariable and multivariable logistic regression models.

resultsAmong 12,755 SLE patients newly starting HCQ treatment, 32.5% received baseline dilated eye examinations. The proportions of patients receiving baseline eye examinations did not significantly change from 2000 to 2010 (31.0-34.4%; P for linear trend = 0.12). Factors associated with an increased likelihood of having an examination included female sex, Asian versus white race, and a higher number of laboratory tests performed during the preceding year. Compared with white patients, lower proportions of black and Native American patients with SLE had baseline retinal examinations.

conclusionOnly one-third of patients with SLE enrolled in Medicaid and in whom HCQ was newly initiated received the recommended baseline retinal examinations, and this proportion did not significantly increase from 2000 to 2010. The sociodemographic variation in this recommended care has been observed for other recommended medical care in SLE and requires both further investigation and interventions to address it.

Indexed as

RetinaAdultAntirheumatic AgentsCohort StudiesEye DiseasesFemaleHumansHydroxychloroquineLupus Erythematosus, SystemicMaleMiddle AgedAntirheumatic AgentsHydroxychloroquine

Identifiers

PMID29409142
PMCPMC6078826
OpenAlexW2789286247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.