Evidence map›Paper›PMID 29409064›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2018

Randomized Trial of CPAP and Vardenafil on Erectile and Arterial Function in Men With Obstructive Sleep Apnea and Erectile Dysfunction.

Kerri L Melehan, Camilla M Hoyos, Garun S Hamilton, Keith K Wong, Brendon J Yee, Robert I McLachlan, Shamus O'Meagher, David Celermajer, Martin K Ng, Ronald R Grunstein and 1 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Approach the Patient With Obstructive Sleep Apnea and Obesity.The Journal of clinical endocrinology and metabolism · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Mental Health in Non-Oncologic Urology Patients.Health psychology research · 2022
    Article
  16. Review
  17. Sleep and the Testis.Current opinion in endocrine and metabolic research · 2021
    Article
  18. Review
  19. Article
  20. The effect of sleep on men's health.Translational andrology and urology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Kerri L MelehanCIRUS, Centre for Sleep & Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Camilla M HoyosCIRUS, Centre for Sleep & Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Garun S HamiltonMonash Lung and Sleep, Monash Health, Clayton, Victoria, Australia.
Keith K WongCIRUS, Centre for Sleep & Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Brendon J YeeCIRUS, Centre for Sleep & Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Robert I McLachlanHudson Institute of Medical Research and Monash University, Clayton, Victoria, Australia.
Shamus O'MeagherDepartment of Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
David CelermajerSydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Martin K NgSydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Ronald R GrunsteinCIRUS, Centre for Sleep & Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Peter Y LiuHarbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California.
Royal Prince Alfred Hospital · AUUniversity of Sydney · AUMonash University · AUHarbor–UCLA Medical Center · USWoolcock Institute of Medical Research · AU

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Hormonal Mechanisms of Sleep RestrictionR01HL124211 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI LIU, PETER YIWEN · 2014 to 2019
$2.1M
NCATS NIH HHS UL1 TR001881NHLBI NIH HHS R01 HL124211
6 · The paper itself

Abstract

Context: Erectile function is important for life satisfaction and often impaired in men with obstructive sleep apnea (OSA). Uncontrolled studies show that treating OSA with continuous positive airway pressure (CPAP) improves erectile function. Phosphodiesterase type 5 inhibitors (e.g., vardenafil) are the first-line therapy for erectile dysfunction (ED), but may worsen OSA. Objective: To assess the effects of CPAP and vardenafil on ED. Design: Sixty-one men with moderate-to-severe OSA and ED were randomized to 12 weeks of CPAP or sham CPAP, and 10 mg daily vardenafil or placebo in a two-by-two factorial design. Main Outcome Measures: International Index of Erectile Function (primary end point), treatment and relationship satisfaction, sleep-related erections, sexual function, endothelial function, arterial stiffness, quality of life, and sleep-disordered breathing. Results: CPAP increased the frequency of sleep-related erections, overall sexual satisfaction, and arterial stiffness but did not change erectile function or treatment or relationship satisfaction. Vardenafil did not alter erectile function, endothelial function, arterial stiffness, or sleep-disordered breathing, but did improve overall self-esteem and relationship satisfaction, other aspects of sexual function, and treatment satisfaction. Adherent CPAP improved erectile function, sexual desire, overall sexual, self-esteem, relationship, and treatment satisfaction, as well as sleepiness, and quality of life. Adherent vardenafil use did not consistently change nocturnal erection quality. Conclusion: CPAP improves overall sexual satisfaction, sleep-related erections, and arterial stiffness. Low-dose daily vardenafil improves certain aspects of sexual function and did not worsen OSA. Adherent CPAP or vardenafil use further improves ED and quality of life.

Indexed as

AdultAgedCombined Modality TherapyContinuous Positive Airway PressureErectile DysfunctionHumansMaleMiddle AgedPatient SatisfactionPhosphodiesterase 5 InhibitorsQuality of LifeSexual BehaviorSleep Apnea, ObstructiveTreatment OutcomeVardenafil DihydrochloridePhosphodiesterase 5 InhibitorsVardenafil Dihydrochloride

Identifiers

PMID29409064
PMCPMC6457007
OpenAlexW2792213175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.