ArticleThe Journal of clinical endocrinology and metabolism2018
Subclinical Hypothyroidism and Incident Depression in Young and Middle-Age Adults.
Article in The Journal of clinical endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms.Scientific reports · 2020Pooled it
- Subclinical Hypothyroidism and Depression: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2019Pooled it
- The effect of synbiotic supplementation on hypothyroidism: A randomized double-blind placebo controlled clinical trial.PloS one · 2023Trial
- Prevalence and Clinical Correlates of Suicide Attempts Among Young Patients With Major Depressive Disorder With Subclinical Hypothyroidism: A Cross-Sectional Study.Brain and behavior · 2026Article
- The impact of autoimmune thyroid disease on cognitive and psychiatric disorders: focus on clinical, pre-clinical and molecular studies.European thyroid journal · 2025Review
- The Association Between Thyrotropin and Clinically Relevant Depression: A Retrospective Cross-Sectional Study.Thyroid : official journal of the American Thyroid Association · 2025Article
- Hypothyroidism Promotes Microglia M1 Polarization by Inhibiting BDNF-Promoted PI3K-Akt Signaling Pathway.Neuroendocrinology · 2025Article
- Prevalence and Risk Factors of Subclinical Hypothyroidism in Young and Middle-Aged Patients With First-Episode Drug-Naïve Major Depressive Disorder.Depression and anxiety · 2025Article
- The Cross-sectional and Longitudinal Association Between Thyroid Function and Depression: A Population-Based Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study.Thyroid : official journal of the American Thyroid Association · 2023Observational
- Association of Low-Normal Free T4 Levels With Future Major Depression Development.Journal of the Endocrine Society · 2023Article
- Association of high BMI with subclinical hypothyroidism in young, first-episode and drug-naïve patients with major depressive disorder: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2023Article
- Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism.Frontiers in aging neuroscience · 2023Article
- Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy.Clinical case reports · 2022Article
- Comparison of Five Different Criteria for Diagnosis of Subclinical Hypothyroidism in a Large-Scale Chinese Population.Frontiers in endocrinology · 2022Article
- Subclinical thyroid dysfunction and major depressive disorder.Hormones (Athens, Greece) · 2021Review
- Patterns of Thyroid Hormone Prescription in Patients with Bipolar or Schizoaffective Disorder: Findings from the LiSIE Retrospective Cohort Study.Journal of clinical medicine · 2021Article
- Subclinical Hypothyroidism: Prevalence, Health Impact, and Treatment Landscape.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- Association of left ventricular hypertrophy with the level of thyroid hormone in euthyroid state.Journal of endocrinological investigation · 2021Article
- Interaction Mechanisms Between Major Depressive Disorder and Non-alcoholic Fatty Liver Disease.Frontiers in psychiatry · 2021Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The role of subclinical hypothyroidism in the development of depression remains controversial. We examined the prospective association between subclinical hypothyroidism and incident depressive symptoms. Methods: We conducted a prospective cohort study of 220,545 middle-age adults without depression who had undergone at least two comprehensive health examinations between 1 January 2011 and 31 December 2014. Thyroid-stimulating hormone, free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured using an electrochemiluminescent immunoassay. The study outcome was incident depressive symptoms, defined as a Center for Epidemiologic Studies-Depression score >16. Results: During a median follow-up period of 2 years, incident depressive symptoms occurred in 7323 participants. The multivariable-adjusted hazard ratio for incident depressive symptoms comparing subclinical hypothyroid and euthyroid participants was 0.97 (95% confidence interval, 0.87 to 1.09). Similarly, among euthyroid participants (n = 87,822), no apparent association was found between thyroid hormone levels and an increased risk of incident depressive symptoms. Conclusions: No apparent association was found between subclinical hypothyroidism and incident depressive symptoms in a large prospective cohort of middle-age men and women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.