ArticlePloS one2018
Association of cancer-related mortality, age and gonadectomy in golden retriever dogs at a veterinary academic center (1989-2016).
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- Casuistry of oncological diseases in dogs, focusing on bone tumors treated at the Veterinary Hospital of the University of the Republic, Uruguay (2018-2023).Brazilian journal of veterinary medicine · 2026Article
- Every Tumour Counts: A Comprehensive Overview of Canine Oncology in Portugal.Animals : an open access journal from MDPI · 2025Article
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- Associations Between Dog Breed and Clinical Features of Mammary Epithelial Neoplasia in Bitches: an Epidemiological Study of Submissions to a Single Diagnostic Pathology Centre Between 2008-2021.Journal of mammary gland biology and neoplasia · 2023Article
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- Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans.Frontiers in oncology · 2023Review
- Expression of Sex Hormone Receptors in Canine Osteosarcoma.Veterinary sciences · 2022Article
- Environmental exposures and lymphoma risk: a nested case-control study using the Golden Retriever Lifetime Study cohort.Canine medicine and genetics · 2022Article
- Utility of Serum Ki-67 as a Marker for Malignancy in Dogs.Animals : an open access journal from MDPI · 2022Article
- Increased risk of cancer in dogs and humans: a consequence of recent extension of lifespan beyond evolutionarily-determined limitations?Aging and cancer · 2022Article
- Cohort profile: The Golden Retriever Lifetime Study (GRLS).PloS one · 2022Article
- Nanobody-based CTLA4 inhibitors for immune checkpoint blockade therapy of canine cancer patients.Scientific reports · 2021Article
- Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs.Veterinary sciences · 2021Article
- Identifying causes of death of companion dogs in Japan using data from pet cemeteries.The Journal of veterinary medical science · 2021Article
- Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds.PLoS genetics · 2021Article
- Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study.Canine medicine and genetics · 2021Article
- Article
- Chromatin run-on sequencing analysis finds that ECM remodeling plays an important role in canine hemangiosarcoma pathogenesis.BMC veterinary research · 2020Article
- Article
- A Regenerative Approach to Canine Osteoarthritis Using Allogeneic, Adipose-Derived Mesenchymal Stem Cells. Safety Results of a Long-Term Follow-Up.Frontiers in veterinary science · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Golden retriever dogs have been reported to have an increased prevalence of cancer compared to other breeds. There is also controversy over the effect spay or neuter status might have on longevity and the risk for developing cancer. The electronic medical records system at an academic center was searched for all dogs who had a necropsy exam from 1989-2016. 9,677 canine necropsy examinations were completed of which 655 were golden retrievers. Age was known for 652 with a median age of death 9.15 years. 424 of the 652 (65.0%) were determined to have died because of cancer. The median age for dying of a cause other than cancer was 6.93 years while those dying of cancer had a median age of 9.83 years (p<0.0001). There was no significant difference in the proportion of intact males and castrated males dying of cancer (p = 0.43) but a greater proportion of spayed females died of cancer compared to intact females (p = 0.001). Intact female dogs had shorter life spans than spayed female dogs (p<0.0001), but there were no differences between intact and castrated males. Intriguingly, being spayed or neutered did not affect the risk of a cancer related death but increasing age did. The most common histologic diagnosis found in golden retrievers dying of cancer was hemangiosarcoma (22.64%) followed by lymphoid neoplasia (18.40%). Overall golden retriever dogs have a substantial risk of cancer related mortality in a referral population and age appears to have a larger effect on cancer related mortality than reproductive status.
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Registered trials
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