Evidence map›Paper›PMID 29408689›Full record

ReviewHuman immunology2018

Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells.

Joseph R Leventhal, Joshua Miller, James M Mathew, Sunil Kurian, Anat R Tambur, John Friedewald, Jane Charrette, Michael M Abecassis

Abstract readReview
In one paragraph

Review in Human immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joseph R LeventhalComprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA.
Joshua MillerComprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA.
James M MathewComprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA; Department of Microbiology-Immunology, Northwestern University, Chicago, IL, USA. Electronic address: James-mathew@northwestern.edu.
Sunil KurianDepartment of Molecular and Experimental Medicine, The Scripps Research Institute and Scripps Center for Organ Transplantation, La Jolla, CA, USA.
Anat R TamburComprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA.
John FriedewaldComprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA; Division of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jane CharretteComprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA.
Michael M AbecassisComprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA; Department of Microbiology-Immunology, Northwestern University, Chicago, IL, USA.

Funding

REGULATORY T AND B CELL CIRCUITS IN TRANSPLANTATIONR01DK025243 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MILLER, JOSHUA · 1986 to 2010
$3.9M
NIDDK NIH HHS R01 DK025243
6 · The paper itself

Abstract

Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4

Indexed as

Hematopoietic Stem Cell TransplantationKidney TransplantationAdultAgedClinical ProtocolsFemaleFollow-Up StudiesGene Expression ProfilingGraft RejectionGraft SurvivalHLA AntigensHumansLiving DonorsMaleMiddle AgedT-Lymphocytes, RegulatoryHLA AntigensGenomic markersHLA-identical renal transplantsT and B regulatory cellsTolerance

Identifiers

PMID29408689
PMCPMC5924714

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.