Evidence map›Paper›PMID 29408655›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2018

Nanomagnetic-mediated drug delivery for the treatment of dental disease.

Yadong Ji, Seung K Choi, Ahmed S Sultan, Kong Chuncai, Xiaoying Lin, Erfan Dashtimoghadam, Mary Anne Melo, Michael Weir, Huakun Xu, Lobat Tayebi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Nanoparticles in Dentistry: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  3. Development and Characterization of FeMaterials (Basel, Switzerland) · 2021
    Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Yadong JiDepartment of Advanced Oral Sciences & Therapeutics, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.
Seung K ChoiDepartment of Advanced Oral Sciences & Therapeutics, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.
Ahmed S SultanDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.
Kong ChuncaiDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.
Xiaoying LinDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.
Erfan DashtimoghadamMarquette University School of Dentistry, Milwaukee, WI, USA.
Mary Anne MeloDepartment of Advanced Oral Sciences & Therapeutics, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.
Michael WeirDepartment of Advanced Oral Sciences & Therapeutics, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.
Huakun XuDepartment of Advanced Oral Sciences & Therapeutics, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.
Lobat TayebiMarquette University School of Dentistry, Milwaukee, WI, USA; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA, USA.
Zhihong NieDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.
Didier A DepireuxInstitute for Systems Research, University of Maryland, College Park, MD, USA; Department of Otorhinolaryngology/Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Radi MasriDepartment of Advanced Oral Sciences & Therapeutics, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA. Electronic address: rmasri@umaryland.edu.
University of Maryland, Baltimore · USUniversity of Maryland, College Park · USMarquette University · USStanford University · US

Funding

Magnetic Delivery of Therapeutic Nanoparticles to the Dental PulpR21DE024227 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI DEPIREUX, DIDIER A, MASRI, RADI · 2014 to 2015
$419k
NIDCR NIH HHS R21 DE024227
6 · The paper itself

Abstract

Maintaining the vitality of the dental pulp, the highly innervated and highly vascular, innermost layer of the tooth, is a critical goal of any dental procedure. Upon injury, targeting the pulp with specific therapies is challenging because it is encased in hard tissues. This project describes a method that can effectively deliver therapeutic agents to the pulp. This method relies on the use of nanoparticles that can be actively steered using magnetic forces to the pulp, traveling through naturally occurring channels in the dentin (the middle layer of the tooth). This method can reduce the inflammation of injured pulp and improve the penetration of dental adhesives into dentin. Such a delivery method would be less expensive, and both less painful and less traumatic than existing therapeutic options available for treatment of injured dental pulp. This technique would be simple and could be readily translated to clinical use.

Indexed as

Drug Delivery SystemsAnimalsAnti-Inflammatory AgentsDental PulpFemaleInflammationMagnetite NanoparticlesMalePrednisoloneRatsRats, Long-EvansStomatognathic DiseasesAnti-Inflammatory AgentsMagnetite NanoparticlesPrednisoloneCompositeDrug deliveryMagnetNanoparticlesPulp

Identifiers

PMID29408655
PMCPMC5899043
OpenAlexW2792702836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.