Evidence map›Paper›PMID 29408609›Full record

ArticleGastroenterology2018

Microbiota-Derived Metabolic Factors Reduce Campylobacteriosis in Mice.

Xiaolun Sun, Kathryn Winglee, Raad Z Gharaibeh, Josee Gauthier, Zhen He, Prabhanshu Tripathi, Dorina Avram, Steven Bruner, Anthony Fodor, Christian Jobin

Open access · greenAbstract read
In one paragraph

Article in Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 84 citations in OpenAlex.

  1. Microbiota-derived indole limitsScience advances · 2026
    Article
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  14. Gut metabolite L-lactate supportsProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiaolun SunDepartment of Medicine, University of Florida, Gainesville, Florida; Center of Excellence for Poultry Science, University of Arkansas, Fayetteville, Arkansas. Electronic address: xiaoluns@uark.edu.
Kathryn WingleeDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina.
Raad Z GharaibehDepartment of Medicine, University of Florida, Gainesville, Florida.
Josee GauthierDepartment of Medicine, University of Florida, Gainesville, Florida.
Zhen HeDepartment of Medicine, University of Florida, Gainesville, Florida.
Prabhanshu TripathiDepartment of Chemistry, University of Florida, Gainesville, Florida.
Dorina AvramDepartment of Medicine, University of Florida, Gainesville, Florida.
Steven BrunerDepartment of Chemistry, University of Florida, Gainesville, Florida.
Anthony FodorDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina.
Christian JobinDepartment of Medicine, University of Florida, Gainesville, Florida; Department of Infectious Diseases and Pathology, University of Florida, Gainesville, Florida; Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida. Electronic address: Christian.Jobin@medicine.ufl.edu.
University of Florida · USUniversity of North Carolina at Charlotte · US

Funding

Role of Bcl11b in CD4+ T cells and innate lymphoid cellsR01AI067846 · NIAID · UNIVERSITY OF FLORIDA · PI AVRAM, DORINA · 2007 to 2023
$6.2M
REGULATION OF IMMUNOSUPPRESSIVE MOLECULES IN IBDR01DK047700 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 1993 to 2014
$3.2M
Impact of microbiota-mediated biotransformation of black tea polyphenolsR01AT008623 · NCCIH · UNIVERSITY OF FLORIDA · PI JOBIN, CHRISTIAN, SANG, SHENGMIN · 2015 to 2019
$2.1M
Molecular Mechanisms of Campylobacter Jejuni-induced PathogenesisR21AI082319 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 2010 to 2011
$417k
NCCIH NIH HHS R01 AT008623NIAID NIH HHS R01 AI067846NIAID NIH HHS R21 AI082319NIDDK NIH HHS R01 DK047700
6 · The paper itself

Abstract

BACKGROUND &

aimsCampylobacter jejuni, a prevalent foodborne bacterial pathogen, exploits the host innate response to induce colitis. Little is known about the roles of microbiota in C jejuni-induced intestinal inflammation. We investigated interactions between microbiota and intestinal cells during C jejuni infection of mice.

methodsGerm-free C57BL/6 Il10

resultsIntroduction of conventional microbiota reduced C jejuni-induced colitis in previously germ-free Il10

conclusionsWe identified a mechanism by which the microbiota controls susceptibility to C jejuni infection in mice, via bacteria-derived secondary bile acids.

Indexed as

AnaerobiosisAnimalsBile Acids and SaltsCampylobacter InfectionsCampylobacter jejuniCholagogues and CholereticsColonCulture TechniquesDeoxycholic AcidDisease Models, AnimalFecal Microbiota TransplantationFecesGastroenteritisGastrointestinal MicrobiomeIntestinesLithocholic AcidBile Acids and SaltsCholagogues and CholereticsDeoxycholic AcidLithocholic AcidUrsodeoxycholic AcidDCAInfectionMetabolismMicrobiome

Identifiers

PMID29408609
PMCPMC5927838
OpenAlexW2787827821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.