Evidence map›Paper›PMID 29408561›Full record

Trial reportContemporary clinical trials2018

Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL): Effects on Bone Structure and Architecture.

Catherine M Donlon, Meryl S LeBoff, Sharon H Chou, Nancy R Cook, Trisha Copeland, Julie E Buring, Vadim Bubes, Gregory Kotler, JoAnn E Manson

2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01747447 nacompletednot on this map

VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture

TypeinterventionalSponsorBrigham and Women's HospitalRan2012 to 2023Enrolled771ConditionsBone Density, Body Composition, Bone HealthArmsVitamin D3 placebo, Fish oil placebo, omega-3 fatty acids (fish oil), Vitamin D3
NCT04573946 naactive not recruitingnot on this mapstarted 2019, after this paper: background citation

VITamin D and OmegA-3 TriaL: Interrelationship of Vitamin D and Vitamin K on Bone

TypeinterventionalSponsorBrigham and Women's HospitalRan2019 to 2026Enrolled25,871ConditionsBone Density, Bone Health, FracturesArmsVitamin D3 placebo, Fish oil placebo, Omega-3 fatty acids (fish oil), Vitamin D3
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Effects of Supplemental Vitamin D on Bone Health Outcomes in Women and Men in the VITamin D and OmegA-3 TriaL (VITAL).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Trial
  3. VITamin D and OmegA-3 TriaL (VITAL) bone health ancillary study: clinical factors associated with trabecular bone score in women and men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Trial
  4. mSphere · 2025
    Article
  5. Frontiers in nutrition · 2025
    Article
  6. Article
  7. The Effects of Vitamin D Supplementation on Musculoskeletal Health: The VITAL and DO-Health Trials.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Review
  8. The clinician's guide to prevention and treatment of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  9. Article
  10. Article
  11. Accounting for Surgical Confounding Factors Affecting Dual-Energy X-ray Absorptiometry in a Large Clinical Trial.Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Catherine M DonlonDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States.
Meryl S LeBoffDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States. Electronic address: mleboff@bwh.harvard.edu.
Sharon H ChouDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Nancy R CookDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
Trisha CopelandDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Julie E BuringDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
Vadim BubesDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Gregory KotlerDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
JoAnn E MansonDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
Harvard University · USBrigham and Women's Hospital · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
The VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9M
VITamin D and OmegA-3 TriaL (VITAL): Interrelationship of Vitamin D and Vitamin K on BoneR01AR059775 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2012 to 2022
$3.9M
VITamin D OmegA-3 TriaL (VITAL): Fractures, Vitamin D and Genetic MarkersR01AR070854 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2018 to 2022
$2.8M
NCATS NIH HHS UL1 TR001102NCI NIH HHS R01 CA138962NCI NIH HHS U01 CA138962NIAMS NIH HHS R01 AR059775NIAMS NIH HHS R01 AR070854
6 · The paper itself

Abstract

Vitamin D supplements are often used to benefit skeletal health, although data on effects of daily high-dose vitamin D alone on bone density and structure are lacking. The ongoing VITamin D and OmegA-3 TriaL (VITAL) is a double-blind, randomized, placebo-controlled trial testing effects of high-dose supplemental vitamin D CLINICAL TRIAL REGISTRATION NUMBER: NCT01747447.

Indexed as

Fatty Acids, Omega-3Vitamin DAbsorptiometry, PhotonBiological AvailabilityBody CompositionBone DensityCardiovascular DiseasesDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMiddle AgedNeoplasmsPhysical Functional PerformanceFatty Acids, Omega-3Vitamin DVitaminsBody compositionBone mineral densityOmega-3 fatty acidsPhysical performanceSex differencesVitamin D

Identifiers

PMID29408561
PMCPMC5877816
OpenAlexW2794181157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.