Evidence map›Paper›PMID 29408498›Full record

ArticleNeuroscience2018

Dysfunctional Limbic Circuitry Underlying Freezing of Gait in Parkinson's Disease.

Moran Gilat, Kaylena A Ehgoetz Martens, Oscar Miranda-Domínguez, Ishu Arpan, James M Shine, Martina Mancini, Damien A Fair, Simon J G Lewis, Fay B Horak

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.

  1. Functional MRI in Parkinson's disease with freezing of gait: a systematic review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Moran GilatParkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia. Electronic address: moran.gilat@sydney.edu.au.
Kaylena A Ehgoetz MartensParkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Oscar Miranda-DomínguezDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
Ishu ArpanDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
James M ShineParkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Martina ManciniDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Damien A FairDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA; Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA; Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA.
Simon J G LewisParkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Fay B HorakDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA; Medical Veterans Affairs Portland Health Care System (VAPORHCS), Portland, OR, USA.
Oregon Health & Science University · USThe University of Sydney · AU

Funding

Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASDR01MH096773 · NIMH · UNIVERSITY OF MINNESOTA · PI DOSENBACH, NICO, FAIR, DAMIEN A · 2012 to 2024
$9.4M
PERIPHERAL AND CENTRAL POSTURAL DISORDERS IN THE ELDERLYR01AG006457 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HORAK, FAY BAHLING · 1986 to 2018
$5.2M
Peripheral and central Postural Disorders in the ElderlyR37AG006457 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HORAK, FAY BAHLING · 2004 to 2013
$4.5M
Body-Worn Sensors to Characterize & Treat Freezing of Gait in Parkinson's DiseaseR00HD078492 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MANCINI, MARTINA · 2016 to 2018
$701k
Body-Worn Sensors to Characterize & Treat Freezing of Gait in Parkinson's DiseaseK99HD078492 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MANCINI, MARTINA · 2014 to 2015
$278k
Frontal Cortex and Gait Freezing in Parkinson's Disease: Rehabilitation ImpactI01RX001075 · VA · PORTLAND VA MEDICAL CENTER · PI HORAK, FAY BAHLING · 2015 to 2017
–
NIA NIH HHS R01 AG006457NIA NIH HHS R37 AG006457NICHD NIH HHS K99 HD078492NICHD NIH HHS R00 HD078492NIMH NIH HHS R01 MH096773RRD VA I01 RX001075
6 · The paper itself

Abstract

Freezing of gait (FOG) is a poorly understood symptom affecting many patients with Parkinson's disease (PD). Despite growing evidence of a behavioral link between anxiety, attention and FOG in PD, no research to date has investigated the neural mechanisms that might explain this relationship. The present study therefore examined resting-state MRI functional connectivity between the amygdala, striatum and frontoparietal attentional control network in PD patients with (freezers: n = 19) and without FOG (non-freezers: n = 21) in the dopaminergic 'off' state. Functional connectivity was subsequently correlated with an objective measure of FOG severity and a subjective scale of affective disorder within each group. Connectivity between the right amygdala and right putamen was significantly increased in freezers compared to non-freezers (p < 0.01). Furthermore, freezers showed increased anti-coupling between the frontoparietal network and left amygdala (p = 0.011), but reduced anti-coupling between this network and the right putamen (p = 0.027) as compared to non-freezers. Key functional connections between the amygdala, putamen and frontoparietal network were significantly associated with FOG severity and a fear of falling. This study provides the first evidence that dysfunctional fronto-striato-limbic processes may underpin the link between anxiety and FOG in PD. It is proposed that freezers have heightened striato-limbic load and reduced top-down attentional control at rest, which when further challenged by the parallel processing demands of walking may precipitate FOG.

Indexed as

AffectAgedAntiparkinson AgentsBrain MappingCerebrovascular CirculationGait Disorders, NeurologicHumansLimbic SystemMagnetic Resonance ImagingNeural PathwaysOxygenParkinson DiseaseRestAntiparkinson AgentsOxygenamygdalaanxietyfunctional MRIgait disordersParkinson’s diseaseputamen

Identifiers

PMID29408498
PMCPMC6390849
OpenAlexW2790859007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.