SynthesisNeuroscience and biobehavioral reviews2018
Meta-analysis and systematic review of the literature characterizing auditory mismatch negativity in individuals with autism.
Synthesis in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 6 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses.Autism research : official journal of the International Society for Autism Research · 2026Pooled it
- Neurophysiological alterations during sensory processing in autism - a meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Systematic Review and Meta-Analysis of Mismatch Negativity in Autism: Insights Into Predictive Mechanisms.Autism research : official journal of the International Society for Autism Research · 2025Pooled it
- Resting-state EEG power differences in autism spectrum disorder: a systematic review and meta-analysis.Translational psychiatry · 2023Pooled it
- Neural correlates and predictors of speech and language development in infants at elevated likelihood for autism: a systematic review.Frontiers in human neuroscience · 2023Pooled it
- Cortical Auditory Processing of Simple Stimuli Is Altered in Autism: A Meta-analysis of Auditory Evoked Responses.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Pooled it
- Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder.Translational psychiatry · 2023Trial
- Reliability of mismatch negativity event-related potentials in a multisite, traveling subjects study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Trial
- From Infant Temperament to Anxiety: Infant Neural Responsivity to Unexpected Stimuli Shapes Outcomes.Biological psychiatry · 2026Article
- Emergence of Deviance Detection in Cortical Cultures Through Maturation, Criticality, and Early Experience.The European journal of neuroscience · 2026Article
- MEG resting state alpha and beta band functional connectivity in male children with autism and sensory processing dysfunction.Journal of neural engineering · 2026Article
- Towards precision psychiatry: initial foundations and future directions.Nature reviews. Drug discovery · 2026Review
- Visuomotor mismatch EEG responses over occipital cortex of freely moving human subjects.eLife · 2026Article
- Neurophysiological Evidence for Reduced Use of Prior Sound Patterns to Shape Speech Processing in Autism.bioRxiv : the preprint server for biology · 2026Article
- Reduced flexibility in predictive tuning and contextual adaptation in autism: an EEG and behavioral study.bioRxiv : the preprint server for biology · 2026Article
- Locus coeruleus modulation of neurophysiological sensory selectivity differs in autism and other mental health conditions.Translational psychiatry · 2026Article
- Relationships Between Autistic Trait Dimensions and Speech Understanding, Affective Sound Intolerance, and Self-Reported Hearing Difficulties.Autism in adulthood · 2026Article
- Sex- and etiology-specific effects on predictive processing in the inferior colliculus of two rat models of autism.Communications biology · 2026Article
- Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study.Molecular autism · 2025Article
- Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A number of past studies have used mismatch negativity (MMN) to identify auditory processing deficits in individuals with autism spectrum disorder (ASD). Our meta-analysis compared MMN responses for individuals with ASD and typically developing controls (TD). We analyzed 67 experiments across 22 publications that employed passive, auditory-based MMN paradigms with ASD and TD participants. Most studies lacked design characteristics that would lead to an accurate description of the MMN. Variability between experiments measuring MMN amplitude was smaller when limited to studies that counterbalanced stimuli. Reduced MMN amplitude was found among young children with ASD compared to controls and in experiments that used nonspeech sounds. Still, few studies included adolescents or those with below-average verbal IQ. Most studies suffered from small sample sizes, and aggregating these data did not reveal significant group differences. This analysis points to a need for research focused specifically on understudied ASD samples using carefully designed MMN experiments. Study of individual differences in MMN may provide further insights into distinct subgroups within the heterogeneous ASD population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.