ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2018
Increased Prevalence of Rare Sucrase-isomaltase Pathogenic Variants in Irritable Bowel Syndrome Patients.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05795049 (Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity Mechanism and Guide Personalised Treatment Using a Non-invasive Multiparametric Test), which is not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity Mechanism and Guide Personalised Treatment Using a Non-invasive Multiparametric Test (Work Package 1)
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Efficacy of a Restrictive Diet in Irritable Bowel Syndrome: A Systematic Review and Network Meta-analysis.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Pooled it
- Dietary Modifications in IBS Leads to Reduced Symptoms, Weight, and Lipid Levels: Two Randomized Clinical Trials.Nutrients · 2025Trial
- A Starch- and Sucrose-Reduced Diet Has Similar Efficiency as Low FODMAP in IBS-A Randomized Non-Inferiority Study.Nutrients · 2024Trial
- A starch- and sucrose-reduced dietary intervention in irritable bowel syndrome patients produced a shift in gut microbiota composition along with changes in phylum, genus, and amplicon sequence variant abundances, without affecting the micro-RNA levels.United European gastroenterology journal · 2022Trial
- Trial
- Trial
- A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients.Nutrients · 2019Trial
- Irregular Dietary Habits with a High Intake of Cereals and Sweets Are Associated with More Severe Gastrointestinal Symptoms in IBS Patients.Nutrients · 2019Trial
- Sucrase-Isomaltase Deficiency in Children with Functional Gastrointestinal Disorders.Journal of clinical medicine · 2026Article
- Nutritional Management of Irritable Bowel Syndrome.Nutrients · 2026Review
- Article
- [Dietary Therapy in Irritable Bowel Syndrome].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Review
- Irritable bowel syndrome remains a complex disorder of gut-brain interaction: Too many actors on stage.World journal of gastroenterology · 2025Article
- Exploration of TCM Comprehensive Treatment of Irritable Bowel Syndrome Based on Pathophysiological Mechanism.International journal of general medicine · 2025Review
- Congenital Sucrase-Isomaltase Deficiency: Same Mutation with Different Clinical Presentations.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Article
- Nutrition and Disorders of Gut-Brain Interaction.Nutrients · 2024Review
- The sucrose challenge symptoms test optimized for diagnosis of congenital sucrase isomaltase deficiency.PloS one · 2024Article
- Healthcare Burden in Greenland of Gastrointestinal Symptoms in Adults with Inherited Loss of Sucrase-Isomaltase Function.The application of clinical genetics · 2024Article
- The prevalence and risk factors of irritable bowel syndrome (PRIBS study) among adults in low- and middle-income countries: A multicenter cross-sectional study.Health science reports · 2023Article
Corrections and comments
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Authors and funding
30 authors at 20 institutions in 7 countries.
Koldo Garcia-EtxebarriaDepartment of Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastián, Spain; Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Tenghao ZhengDepartment of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Ferdinando BonfiglioDepartment of Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastián, Spain; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Luis BujandaDepartment of Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastián, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), San Sebastián, Spain.
Aldona DlugoszDepartment of Medicine Solna, Karolinska Institutet, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.
Greger LindbergDepartment of Medicine Solna, Karolinska Institutet, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.
Peter T SchmidtCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), San Sebastián, Spain.
Pontus KarlingDivision of Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Bodil OhlssonLund University, Skåne University Hospital, Department of Internal Medicine, Lund, Sweden.
Magnus SimrenDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Susanna WalterDivision of Neuro and Inflammation Science, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Gerardo NardoneGastroenterology Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
Rosario CuomoDigestive Motility Diseases, Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy.
Paolo Usai-SattaS.C. Gastroenterologia, Azienda Ospedaliera G. Brotzu, Cagliari, Italy.
Francesca GaleazziUOC Gastroenterologia, Padova University Hospital, Padova, Italy.
Matteo NeriDepartment of Medicine and Aging Sciences and CESI, G. D'Annunzio University and Foundation, Chieti, Italy.
Piero PortincasaDepartment of Biomedical Sciences and Human Oncology (DIMO), Clinica Medica "A. Murri", University of Bari Medical School, Bari, Italy.
Massimo BelliniGastroenterology Unit, Department of Gastroenterology, University of Pisa, Pisa, Italy.
Giovanni BarbaraDepartment of Medical and Surgical Sciences, University of Bologna, St Orsola - Malpighi Hospital, Bologna, Italy.
Daisy JonkersDepartment of Internal Medicine, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Shanti EswaranDivision of Gastroenterology, University of Michigan, Michigan Medicine, Ann Arbor, Michigan.
William D CheyDivision of Gastroenterology, University of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Purna KashyapDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Lin ChangG. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, UCLA, Los Angeles, California.
Emeran A MayerG. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, UCLA, Los Angeles, California.
Mira M WoutersTranslational Research Center for Gastro Intestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
Guy BoeckxstaensTranslational Research Center for Gastro Intestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
Michael CamilleriClinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), and Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Mauro D'AmatoDepartment of Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastián, Spain; Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; IKERBASQUE, Basque Science Foundation, Bilbao, Spain. Electronic address: mauro.damato@ki.se.
Karolinska Institutet · SEFederico II University Hospital · ITKarolinska University Hospital · SEKU Leuven · BEMichigan Medicine · USUniversity of the Basque Country · ESAzienda Ospedaliera G. Brotzu · ITChristian-Albrechts-Universität zu Kiel · DEIkerbasque · ESIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITLinköping University · SELund University · SEMaastricht University · NLMayo Clinic · USMayo Clinic in Florida · USUmeå University · SEUniversity of Bari Aldo Moro · ITUniversity of Chieti-Pescara · ITUniversity of Gothenburg · SEUniversity of Padua · IT
Funding
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2MMechanisms of alteration of GI physiology by gut microbesR01DK114007 · NIDDK · MAYO CLINIC ROCHESTER · PI Purna C Kashyap · 2017 to 2026
$4.7MNIDDK NIH HHS R01 DK048351NIDDK NIH HHS R01 DK114007
Abstract
Patients with irritable bowel syndrome (IBS) often associate their symptoms to certain foods. In congenital sucrase-isomaltase deficiency (CSID), recessive mutations in the SI gene (coding for the disaccharidase digesting sucrose and 60% of dietary starch)
Indexed as
Gene FrequencyGenotypeHumansIrritable Bowel SyndromePrevalenceSucrase-Isomaltase ComplexSucrase-Isomaltase Complex
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT05795049ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.