Evidence map›Paper›PMID 29408274›Full record

ArticleNeurobiology of learning and memory2018

Running exercise mitigates the negative consequences of chronic stress on dorsal hippocampal long-term potentiation in male mice.

Roxanne M Miller, David Marriott, Jacob Trotter, Tyler Hammond, Dane Lyman, Timothy Call, Bethany Walker, Nathanael Christensen, Deson Haynie, Zoie Badura and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  15. Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2020
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roxanne M MillerBrigham Young University, Department of Physiology and Developmental Biology, Provo, UT 84602, USA.
David MarriottBrigham Young University, Department of Physiology and Developmental Biology, Provo, UT 84602, USA.
Jacob TrotterBrigham Young University, Neuroscience Center, Provo, UT 84602, USA.
Tyler HammondBrigham Young University, Neuroscience Center, Provo, UT 84602, USA.
Dane LymanBrigham Young University, Department of Physiology and Developmental Biology, Provo, UT 84602, USA.
Timothy CallBrigham Young University, Neuroscience Center, Provo, UT 84602, USA.
Bethany WalkerBrigham Young University, Neuroscience Center, Provo, UT 84602, USA.
Nathanael ChristensenBrigham Young University, Neuroscience Center, Provo, UT 84602, USA.
Deson HaynieBrigham Young University, Neuroscience Center, Provo, UT 84602, USA.
Zoie BaduraBrigham Young University, Department of Physiology and Developmental Biology, Provo, UT 84602, USA.
Morgan HomanBrigham Young University, Neuroscience Center, Provo, UT 84602, USA.
Jeffrey G EdwardsBrigham Young University, Department of Physiology and Developmental Biology, Provo, UT 84602, USA; Brigham Young University, Neuroscience Center, Provo, UT 84602, USA. Electronic address: Jeffrey_Edwards@byu.edu.

Funding

Identification of GPR55 cellular expression within hippocampal cells and its physR15NS078645 · NINDS · BRIGHAM YOUNG UNIVERSITY · PI EDWARDS, JEFFREY G · 2012 to 2012
$363k
NINDS NIH HHS R15 NS078645
6 · The paper itself

Abstract

In the hippocampus, learning and memory are likely mediated by synaptic plasticity, known as long-term potentiation (LTP). While chronic intermittent stress is negatively correlated, and exercise positively correlated to LTP induction, we examined whether exercise could mitigate the negative consequences of stress on LTP when co-occurring with stress. Mice were divided into four groups: sedentary no stress, exercise no stress, exercise with stress, and sedentary with stress. Field electrophysiology performed on brain slices confirmed that stress alone significantly reduced dorsal CA1 hippocampal LTP and exercise alone increased LTP compared to controls. Exercise with stress mice exhibited LTP that was significantly greater than mice undergoing stress alone but were not different from sedentary no stress mice. An ELISA illustrated increased corticosterone in stressed mice compared to no stress mice. In addition, a radial arm maze was used to examine behavioral changes in memory during 6 weeks of stress and/or exercise. Exercised mice groups made fewer errors in week 2. RT-qPCR was used to examine the mRNA expression of components in the stress and exercise pathways in the four groups. Significant changes in the expression of the following targets were detected: BDNF, TrkB, glucocorticoid, mineralocorticoid, and dopamine 5 receptors. Collectively, exercise can mitigate some of the negative impact stress has on hippocampal function when both occur concurrently.

Indexed as

AnimalsCorticosteroneExcitatory Postsynaptic PotentialsHippocampusLong-Term PotentiationMaleMaze LearningMicePhysical Conditioning, AnimalStress, PhysiologicalStress, PsychologicalCorticosteroneCorticosteroneDopamine 5 receptorDorsal hippocampusLTDLTPRT-qPCR

Identifiers

PMID29408274
PMCPMC5864554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.