Evidence map›Paper›PMID 29408195›Full record

ArticleJournal of molecular and cellular cardiology2018

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.

Yuuki Shimizu, Rohini Polavarapu, Kattri-Liis Eskla, Chad K Nicholson, Christopher A Koczor, Rui Wang, William Lewis, Sruti Shiva, David J Lefer, John W Calvert

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular and cellular cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 86 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Molecular mechanisms of mitochondrial quality control.Translational neurodegeneration · 2025
    Review
  6. Review
  7. The Dual Role of Exogenous Hydrogen Sulfide (HAntioxidants (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Regulation of Mitochondrial Respiration by Hydrogen Sulfide.Antioxidants (Basel, Switzerland) · 2023
    Review
  14. HBiomedicines · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Mitochondrial HCirculation research · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yuuki ShimizuDepartment of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA, USA.
Rohini PolavarapuDepartment of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA, USA.
Kattri-Liis EsklaDepartment of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA, USA.
Chad K NicholsonDepartment of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA, USA.
Christopher A KoczorDepartment of Pathology, Emory University School of Medicine, Atlanta, GA, USA.
Rui WangCardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Canada.
William LewisDepartment of Pathology, Emory University School of Medicine, Atlanta, GA, USA.
Sruti ShivaDepartment of Pharmacology & Chemical Biology, Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
David J LeferCardiovascular Center of Excellence, Department of Pharmacology, LSU Health Sciences Center, New Orleans, LA, USA.
John W CalvertDepartment of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: jcalver@emory.edu.
Emory University · USLaurentian University · CALouisiana State University Health Sciences Center New Orleans · USUniversity of Pittsburgh · US

Funding

Preclinical Consortium to Facilitate Translation of Cardioprotective TherapiesU24HL094373 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BOLLI, ROBERTO · 2010 to 2014
$9.6M
Functional Cardio-MetabolomicsP20HL113452 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2012 to 2016
$4.8M
Targeting the orphan nuclear receptor LRH-1 with small moleculesR01DK115213 · NIDDK · EMORY UNIVERSITY · PI John Winter Calvert, Eric A Ortlund · 2017 to 2026
$4.6M
Cardioprotective Actions of Hydrogen SulfideR01HL092141 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2013
$1.9M
Hydrogen sulfide attenuates heart failure through Nrf2-mediated signalingR01HL098481 · NHLBI · EMORY UNIVERSITY · PI CALVERT, JOHN WINTER · 2010 to 2014
$1.9M
Nitrite Mediated CardioprotectionR01HL093579 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2012
$1.5M
CIHR MOP 119565NHLBI NIH HHS P20 HL113452NHLBI NIH HHS R01 HL092141NHLBI NIH HHS R01 HL093579NHLBI NIH HHS R01 HL098481NHLBI NIH HHS U24 HL094373NIDDK NIH HHS R01 DK115213
6 · The paper itself

Abstract

backgroundHydrogen sulfide (H

resultsMice deficient in the H

conclusionsTogether, these results suggest that hydrogen sulfide is an important regulator of cardiac mitochondrial content and establishes that exogenous hydrogen sulfide can induce mitochondrial biogenesis via an AMPK-PGC1α signaling cascade.

Indexed as

Organelle BiogenesisAMP-Activated Protein KinasesAnimalsCell NucleusDNA, MitochondrialEnzyme ActivationHeart FailureHumansHydrogen SulfideMice, Inbred C57BLMitochondria, HeartNitric OxideNitric Oxide Synthase Type IIIPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphorylationProtein Phosphatase 2AMP-Activated Protein KinasesDNA, MitochondrialHydrogen SulfideNitric OxideNitric Oxide Synthase Type IIIPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProtein Phosphatase 2Protein Serine-Threonine KinasesStk11 protein, mouseSulfurAMPKHeartHydrogen sulfideMitochondria

Identifiers

PMID29408195
PMCPMC5845802
OpenAlexW2792820043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.