Evidence map›Paper›PMID 29408054›Full record

ArticleNeurobiology of learning and memory2018

Paradoxical accentuation of motivation following accumbens-pallidum disconnection.

Stephen E Chang, Travis P Todd, Kyle S Smith

Abstract read
In one paragraph

Article in Neurobiology of learning and memory, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Inactivation of the Ventral Pallidum by GABANeurochemical research · 2020
    Article
  7. Article
  8. Review
  9. Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Article
  10. Article
  11. Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephen E ChangDartmouth College, Department of Psychological and Brain Sciences, 6207 Moore Hall, Hanover, NH 03755, United States. Electronic address: Stephen.Chang@dartmouth.edu.
Travis P ToddDartmouth College, Department of Psychological and Brain Sciences, 6207 Moore Hall, Hanover, NH 03755, United States.
Kyle S SmithDartmouth College, Department of Psychological and Brain Sciences, 6207 Moore Hall, Hanover, NH 03755, United States.

Funding

Neural Mechanisms of Adaptive Reward Seeking and Salt AppetiteF32MH106178 · NIMH · DARTMOUTH COLLEGE · PI CHANG, STEPHEN · 2015 to 2017
$168k
Cortico-hippocampal contributions to context and extinction learning.F32MH105125 · NIMH · DARTMOUTH COLLEGE · PI TODD, TRAVIS · 2014 to 2017
$159k
NIMH NIH HHS F32 MH105125NIMH NIH HHS F32 MH106178
6 · The paper itself

Abstract

The nucleus accumbens (NAc) and ventral pallidum (VP) are reciprocally connected, and activity within this circuit is thought to promote reward learning. Inconsistent with this notion, we find that disconnecting NAc medial shell and VP greatly enhances the attribution of value to a cue that is paired with reward. This result suggests that medial NAc shell and VP are both needed for attributing value to cues yet can also oppose one-another's functional contribution.

Indexed as

AnimalsBasal ForebrainCuesMotivationNucleus AccumbensRatsRats, Long-EvansReinforcement ScheduleNucleus accumbensSign-trackingVentral pallidum

Identifiers

PMID29408054
PMCPMC5864546

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.