ArticleEuropean journal of medicinal chemistry2018
Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
Article in European journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Recent Synthesis of Nucleoside Phosphonate Analogs Using Olefin Cross-metathesis.Current medicinal chemistry · 2025Review
- Synthesis of Mixed Phosphonate Esters and Amino Acid-Based Phosphonamidates, and Their Screening as Herbicides.International journal of molecular sciences · 2024Article
- Ultrasound-assisted synthesis of pyrimidines and their fused derivatives: A review.Ultrasonics sonochemistry · 2021Review
- Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(Molecules (Basel, Switzerland) · 2021Article
- Advances and Perspectives in the Management of Varicella-Zoster Virus Infections.Molecules (Basel, Switzerland) · 2021Review
- Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.Bioorganic & medicinal chemistry · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several hitherto unknown (E)-but-2-enyl nucleoside phosphonoamidate analogs (ANPs) were prepared directed with nitrogen reagents by cross-metathesis in water-under ultrasound irradiation. Two diastereoisomers were formally identified by X-ray diffraction. These compounds were evaluated against a large spectrum of DNA and RNA viruses. Among them, the phosphonoamidate thymine analogue 19 emerged as the best prodrug against varicella-zoster virus (VZV) with EC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.