ReviewFree radical biology & medicine2018
A critical review of assays for hazardous components of air pollution.
Review in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Oxidative Potential Versus Biological Effects: A Review on the Relevance of Cell-Free/Abiotic Assays as Predictors of Toxicity from Airborne Particulate Matter.International journal of molecular sciences · 2019Pooled it
- Air Pollution and Dementia: A Systematic Review.Journal of Alzheimer's disease : JAD · 2019Pooled it
- The Impact of Air Pollution on Our Epigenome: How Far Is the Evidence? (A Systematic Review).Current environmental health reports · 2018Pooled it
- Long-term exposure to ambient air pollution and an increased risk of hyperuricemia.Clinical rheumatology · 2026Article
- Oxidative Potential of Atmospheric Particulate Matter: A Review of the Role of Metal-Organic Interactions, Mechanistic Insights, and Key Determinants.Environmental science & technology · 2026Review
- Metabolic Signatures of Air Pollution and Major Adverse Cardiovascular Events in Patients Undergoing Cardiac Catheterization.JACC. Advances · 2026Article
- In utero air pollution exposure and pre- and postnatal brain development: a review.Neuroscience applied · 2026Review
- Air Pollution and Parkinson's Disease Pathology: Clinical Evidence and the Molecular Mechanisms Linking Airborne Toxicants to Neuroinflammation and Neurodegeneration.Parkinson's disease · 2026Review
- Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Effects of air and light pollution on brain and behavioral function: Potential synergy.Neuroscience and biobehavioral reviews · 2025Review
- The Joint Effects of Exposure to Ambient Long-term Air Pollution and Short-term Heat on Epigenetic Aging in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- The Adverse Health Effects of Air Pollution from Sugarcane Burning: A Scoping Review of Observational and Experimental Evidence.Environmental health perspectives · 2025Article
- Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Relation of prenatal and postnatal PMInternational journal of hygiene and environmental health · 2024Article
- Particulate matter from car exhaust alters function of human iPSC-derived microglia.Particle and fibre toxicology · 2024Article
- Particulate Matter in Human Elderly: Higher Susceptibility to Cognitive Decline and Age-Related Diseases.Biomolecules · 2023Review
- Air pollution and epigenetic aging among Black and White women in the US.Environment international · 2023Article
- Microfluidic paper-based analytical devices for simultaneous detection of oxidative potential and copper in aerosol samples.Mikrochimica acta · 2023Article
- Mapping the long-term associations between air pollutants and COVID-19 risks and the attributable burdens in the continental United States.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Increased mortality and diverse morbidities are globally associated with exposure to ambient air pollution (AAP), cigarette smoke (CS), and household air pollution (HAP). The AAP-CS-HAP aerosols present heterogeneous particulate matter (PM) of diverse chemical and physical characteristics. Some epidemiological models have assumed the same health hazards by PM weight for AAP, CS, and HAP regardless of the composition. While others have recognized that biological activities and toxicity will vary with components, we focus particularly on oxidation because of its major role in assay outcomes. Our review of PM assays considers misinterpretations of some chemical measures used for oxidative activity. Overall, there is low consistency across chemical and cell-based assays for oxidative and inflammatory activity. We also note gaps in understanding how much airborne PM of various sizes enter cells and organs. For CS, the body burden per cigarette may be much below current assumptions. Synergies shown for health hazards of AAP and CS suggest crosstalk in detoxification pathways mediated by AHR, NF-κB, and Nrf2. These complex genomic and biochemical interactions frustrate resolution of the toxicity of specific AAP components. We propose further strategies based on targeted gene expression based on cell-type differences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.