Evidence map›Paper›PMID 29407718›Full record

Trial reportPsychiatry research2018

Neurocognitive correlates of treatment response in children with Tourette's Disorder.

Susanna W Chang, Joseph F McGuire, John T Walkup, Douglas W Woods, Lawrence Scahill, Sabine Wilhelm, Alan L Peterson, James Dziura, John Piacentini

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychiatry research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

  1. Childhood cognitive control as a predictor of long-term clinical and functional outcomes in Tourette syndrome.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Trial
  2. Trial
  3. Cognitive control processes in behavior therapy for youth with Tourette's disorder.Journal of child psychology and psychiatry, and allied disciplines · 2022
    Trial
  4. Article
  5. Evidence-Based Behavior Therapy for Tourette Syndrome.The Psychiatric clinics of North America · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. [A review on the management of tic disorders in children: psychoeducation and behavioral intervention].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Susanna W ChangDepartment of Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, rm 67-463, Los Angeles, CA 90024, USA. Electronic address: schang@mednet.ucla.edu.
Joseph F McGuireDepartment of Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, rm 67-463, Los Angeles, CA 90024, USA; Division of Child and Adolescent Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA.
John T WalkupDepartment of Psychiatry, Weill Cornell Medical College, Cornell University, Ithaca, NY, USA.
Douglas W WoodsDepartment of Psychology, Marquette University, Milwaukee, WI, USA.
Lawrence ScahillDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Sabine WilhelmDepartment of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Cambridge, MA, USA.
Alan L PetersonDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
James DziuraYale Child Study Center, New Haven, CT, USA.
John PiacentiniDepartment of Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, rm 67-463, Los Angeles, CA 90024, USA.
Cornell University · USEmory University · USJohns Hopkins Medicine · USMarquette University · USMassachusetts General Hospital · USThe University of Texas Health Science Center at San Antonio · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
Behavior Therapy for Children with Chronic Tic DisordersR01MH070802 · NIMH · TOURETTE SYNDROME ASSOCIATION, INC · PI PIACENTINI, JOHN C. · 2004 to 2007
$2.9M
Neurocognitive Correlates of Behavior Treatment Response in Child TSK23MH080914 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHANG, SUSANNA W. · 2007 to 2011
$684k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH080914NIMH NIH HHS R01 MH070802NIMH NIH HHS T32 MH073517
6 · The paper itself

Abstract

This paper examined neurocognitive functioning and its relationship to behavior treatment response among youth with Tourette's Disorder (TD) in a large randomized controlled trial. Participants diagnosed with TD completed a brief neurocognitive battery assessing inhibitory functions, working memory, and habit learning pre- and post-treatment with behavior therapy (CBIT, Comprehensive Behavioral Intervention for Tics) or psychoeducation plus supportive therapy (PST). At baseline, youth with tics and Attention Deficit Hyperactivity Disorder (ADHD) exhibited some evidence of impaired working memory and simple motor inhibition relative to youth with tics without ADHD. Additionally, a small negative association was found between antipsychotic medications and youth's performance speed. Across treatment groups, greater baseline working memory and aspects of inhibitory functioning were associated with a positive treatment response; no between-group differences in neurocognitive functioning at post-treatment were identified. Within the behavior therapy group, pre-treatment neurocognitive status did not predict outcome, nor was behavior therapy associated significant change in neurocognitive functioning post-treatment. Findings suggest that co-occurring ADHD is associated with some impairments in neurocognitive functioning in youth with Tourette's Disorder. While neurocognitive predictors of behavior therapy were not found, participants who received behavior therapy exhibited significantly reduced tic severity without diminished cognitive functioning.

Indexed as

AdolescentAntipsychotic AgentsAttention Deficit Disorder with HyperactivityBehavior TherapyChildFemaleHumansInhibition, PsychologicalLearningMaleMemory, Short-TermMental Status and Dementia TestsTourette SyndromeTreatment OutcomeAntipsychotic AgentsADHDBehavior therapyComorbidityNeurocognitionTouretteYouth

Identifiers

PMID29407718
PMCPMC5809184
OpenAlexW2782334780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.