Evidence map›Paper›PMID 29407367›Full record

ArticleToxicology and applied pharmacology2018

Investigating mitochondrial dysfunction in human lung cells exposed to redox-active PM components.

Katelyn S Lavrich, Elizabeth M Corteselli, Phillip A Wages, Philip A Bromberg, Steven O Simmons, Eugene A Gibbs-Flournoy, James M Samet

Abstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Particulate matter and the airway epithelium: the special case of the underground?European respiratory review : an official journal of the European Respiratory Society · 2019
    Article
  12. Article
  13. Macrophages from the upper and lower human respiratory tract are metabolically distinct.American journal of physiology. Lung cellular and molecular physiology · 2018
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katelyn S LavrichCurriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: klavrich@email.unc.edu.
Elizabeth M CorteselliDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: emc252@live.unc.edu.
Phillip A WagesCurriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: p.wages@vanderbilt.edu.
Philip A BrombergCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: philip_bromberg@med.unc.edu.
Steven O SimmonsNational Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, NC 27709, USA. Electronic address: Simmons.Steve@epa.gov.
Eugene A Gibbs-FlournoyOak Ridge Institute for Science and Education, Oak Ridge, TN 37830, USA. Electronic address: Gibbs-Flournoy.Eugene@epa.gov.
James M SametEnvironmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Chapel Hill, NC 27599, USA. Electronic address: samet.james@epa.gov.

Funding

TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
Intramural EPA EPA999999NIEHS NIH HHS T32 ES007126
6 · The paper itself

Abstract

Exposure to ambient particulate matter (PM) causes cardiopulmonary morbidity and mortality through mechanisms that involve oxidative stress. 1,2-naphthoquinone (1,2-NQ) is a ubiquitous component of PM and a potent redox-active electrophile. We previously reported that 1,2-NQ increases mitochondrial H

Indexed as

Air PollutantsAnimalsCell LineDose-Response Relationship, DrugHumansHydrogen PeroxideLungMaleMiceMice, Inbred C57BLMitochondriaOxidation-ReductionOxygen ConsumptionParticulate MatterRespiratory MucosaAir PollutantsHydrogen PeroxideParticulate MatterAir pollutionBioenergeticsExtracellular fluxMitochondriaQuinones

Identifiers

PMID29407367
PMCPMC5909833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.