ArticleAmerican journal of respiratory and critical care medicine2018
At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.
Erratum issued 3 registry-linked trialsAbstract readComparative Study
In one paragraph
Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 179 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cohort Study of Airway Microecology and the Pathogenesis and Evolution of Chronic Obstructive Pulmonary Disease
Role of Small Bioactive Molecules in the Progression of Early COPD Diseases
Michigan eArly Disease Progression Cohort in COPD (MAP COPD)
Who cites it
179 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Definitions of early COPD and predictors for disease progression: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review.BMC pulmonary medicine · 2020Pooled it
- Pooled it
- Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial.Nature communications · 2024Trial
- Assessment of bacterial exposure on phagocytic capability and surface marker expression of sputum macrophages and neutrophils in COPD patients.Clinical and experimental immunology · 2021Trial
- Oral Vitamin C (500 mg/d) to Pregnant Smokers Improves Infant Airway Function at 3 Months (VCSIP). A Randomized Trial.American journal of respiratory and critical care medicine · 2019Trial
- Effect of Erdosteine on COPD Exacerbations in COPD Patients with Moderate Airflow Limitation.International journal of chronic obstructive pulmonary disease · 2019Trial
- Response to letter regarding "clinical impact of disease stability on exacerbation and mortality in chronic obstructive pulmonary disease".Annals of medicine · 2026Article
- Airway mucus plugs in asthma and chronic obstructive pulmonary disease: pathobiology, imaging, and implications for clinical trials.American journal of respiratory and critical care medicine · 2026Review
- Plasma metabolomic signatures enable the diagnosis and prognosis of chronic obstructive pulmonary disease.Nature communications · 2026Article
- PIP4K2A: A Novel CD8+ T Cell-Related Biomarker Associated with Lung Function Decline in COPD.Biochemical genetics · 2026Article
- Pathogenesis and Phenotypes of Pulmonary Vascular Disease in COPD: A Consensus Statement From the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative - PH Group 3 Workstream.Pulmonary circulation · 2026Article
- Rapid decline in lung function is associated with more chronic respiratory symptoms, more severe small airway dysfunction and lung structural changes.Journal of thoracic disease · 2026Article
- Single-Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein-Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pre-COPD: Impact on prevention, detection, and treatment.Presse medicale (Paris, France : 1983) · 2026Review
- Predominant lung cDC2 phenotype in cigarette smoke-exposed mice favors polarization of IL-17-producing CD4American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Clinically aligned COPD severity prediction using ordinal neural networks.Frontiers in medicine · 2026Article
- Longitudinal Outcomes and Prognostic Risk of Normalized Airflow Obstruction in a Korean General Population Cohort.International journal of chronic obstructive pulmonary disease · 2026Article
- Evaluation of Clinical Characteristics and Lung Function Trajectories in Young COPD Patients Within the General Population.International journal of chronic obstructive pulmonary disease · 2026Article
- Prevalence and associated factors for COPD and pre-COPD in Guizhou Province, China: A cross-sectional study.Tobacco induced diseases · 2026Article
119 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
26 authors.
Fernando J Martinez1 Weill Cornell Medical College, New York, New York.
MeiLan K Han2 University of Michigan School of Medicine, Ann Arbor, Michigan.
James P Allinson3 Imperial College, London, United Kingdom.
R Graham Barr4 Columbia University, New York, New York.
Richard C Boucher5 University of North Carolina, Chapel Hill, North Carolina.
Peter M A Calverley6 School of Clinical Sciences, Liverpool, United Kingdom.
Bartolome R Celli7 Harvard School of Medicine, Boston, Massachusetts.
Stephanie A Christenson8 University of California at San Francisco, San Francisco, California.
Ronald G Crystal1 Weill Cornell Medical College, New York, New York.
Malin Fagerås9 AstraZeneca Corporation, London, United Kingdom.
Christine M Freeman2 University of Michigan School of Medicine, Ann Arbor, Michigan.
Lars Groenke11 Boehringer Ingelheim, Ingelheim, Germany.
Eric A Hoffman12 University of Iowa Carver College of Medicine, Iowa City, Iowa.
Mehmet Kesimer5 University of North Carolina, Chapel Hill, North Carolina.
Kostantinos Kostikas13 Novartis Pharma, Basel, Switzerland.
Robert Paine14 University of Utah, Salt Lake City, Utah.
Shahin Rafii1 Weill Cornell Medical College, New York, New York.
Stephen I Rennard11 Boehringer Ingelheim, Ingelheim, Germany.
Leopoldo N Segal16 New York University, New York, New York.
Renat Shaykhiev1 Weill Cornell Medical College, New York, New York.
Christopher Stevenson17 Janssen Pharmaceutica, Beerse, Belgium.
Ruth Tal-Singer18 GlaxoSmithKline, King of Prussia, Pennsylvania; and.
Jørgen Vestbo19 Odense University Hospital, Odense, Denmark.
Prescott G Woodruff8 University of California at San Francisco, San Francisco, California.
Jeffrey L Curtis2 University of Michigan School of Medicine, Ann Arbor, Michigan.
Jadwiga A Wedzicha3 Imperial College, London, United Kingdom.
Funding
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MFunctional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated EmphysemaR01HL130883 · NHLBI · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2016 to 2020
$3.6MDefective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPDR01HL123544 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHAYKHIEV, RENAT · 2015 to 2019
$2.1MAmphiregulin-driven COPD-relevant Remodeling of Human Airway EpitheliumR01HL127393 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHAYKHIEV, RENAT · 2016 to 2019
$1.7MRedefining Therapy In Early COPD: RETHINCU01HL128952 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, WOODRUFF, PRESCOTT G · 2015 to 2020
$1.6MDefining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2MIdentifying the Th2 endotype in COPD: clinical and pathologic implicationsK23HL123778 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTENSON, STEPHANIE A · 2015 to 2019
$847kLung Microbiome and Inflammation in Early COPDK23AI102970 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGAL, LEOPOLDO NICOLAS · 2014 to 2017
$754kCSRD VA I01 CX000911CSRD VA I01 CX001553Department of Health RP-PG-0109-10056Medical Research Council G0800570Medical Research Council G1001365Medical Research Council G1001372NHLBI NIH HHS K23 HL123778NHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL138188NHLBI NIH HHS R01 HL123544NHLBI NIH HHS R01 HL127393NHLBI NIH HHS R01 HL130883NHLBI NIH HHS U01 HL128952NHLBI NIH HHS U01 HL137880NIAID NIH HHS K23 AI102970NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P30 ES009089
Abstract
PubMed holds no abstract for this paper.
Indexed as
Age of OnsetDisease ProgressionEarly DiagnosisAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPulmonary Disease, Chronic Obstructive
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.