Evidence map›Paper›PMID 29406711›Full record

ArticleBiochemistry2018

ISCU(M108I) and ISCU(D39V) Differ from Wild-Type ISCU in Their Failure To Form Cysteine Desulfurase Complexes Containing Both Frataxin and Ferredoxin.

Kai Cai, Ronnie O Frederick, Marco Tonelli, John L Markley

Abstract read
In one paragraph

Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Characteristics of the Isu1 C-terminus in relation to [2Fe-2S] cluster assembly and ISCU Myopathy.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kai CaiNational Magnetic Resonance Facility at Madison and Department of Biochemistry , University of Wisconsin-Madison , 433 Babcock Drive , Madison , Wisconsin 53706 , United States.
Ronnie O FrederickNational Magnetic Resonance Facility at Madison and Department of Biochemistry , University of Wisconsin-Madison , 433 Babcock Drive , Madison , Wisconsin 53706 , United States.
Marco TonelliNational Magnetic Resonance Facility at Madison and Department of Biochemistry , University of Wisconsin-Madison , 433 Babcock Drive , Madison , Wisconsin 53706 , United States.
John L MarkleyNational Magnetic Resonance Facility at Madison and Department of Biochemistry , University of Wisconsin-Madison , 433 Babcock Drive , Madison , Wisconsin 53706 , United States.ORCID 0000-0003-1799-6134
University of Wisconsin–Madison · US

Funding

TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2012 to 2019
$9.4M
Partnership for High-Throughput Enabled Biology of the Mitochondrial ProteomeU01GM094622 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2010 to 2014
$7.8M
NIGMS NIH HHS P41 GM103399NIGMS NIH HHS U01 GM094622
6 · The paper itself

Abstract

Whereas iron-sulfur (Fe-S) cluster assembly on the wild-type scaffold protein ISCU, as catalyzed by the human cysteine desulfurase complex (NIA)

Indexed as

Amino Acid SequenceAnimalsCarbon-Sulfur LyasesFerredoxinsFrataxinHumansIron-Binding ProteinsIron-Sulfur ProteinsMiceModels, MolecularCarbon-Sulfur Lyasescysteine desulfuraseFerredoxinsFrataxinIron-Binding ProteinsIron-Sulfur ProteinsISCU protein, humanNFS1 protein, human

Identifiers

PMID29406711
PMCPMC5842376
OpenAlexW2409597817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.