ArticlePlant biotechnology journal2018
QTL mapping and GWAS reveal candidate genes controlling capsaicinoid content in Capsicum.
Article in Plant biotechnology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70 citing papers in PubMed, 180 citations in OpenAlex.
- Shaping the Plant Specialized Metabolites Through Modern Breeding Technique.Molecular biotechnology · 2026Review
- From High-Density Genomic Mapping to Precision Molecular Breeding: A Comprehensive Review ofGenes · 2026Review
- Rapid Identification of Candidate SNPs and QTLs forCurrent issues in molecular biology · 2026Article
- QTL mapping and identification of linked markers for anthracnose fruit rot resistance inFrontiers in plant science · 2026Article
- Spicy genes: mapping quantitative genomic regions and candidate genes for capsaicinoid and capsinoid biosynthesis in pepper.Frontiers in plant science · 2026Review
- Integrated genomic analysis of a diverse maize population reveals novel genes and superior predictive models for ear diameter.BMC genomics · 2025Article
- Co-identification of candidate regions associated with ovule number per ovary through QTL analysis and GWAS inBreeding science · 2025Article
- Identification and characterization of a novel leakyMolecular breeding : new strategies in plant improvement · 2025Article
- Inheritance characteristics and potential of genomic prediction for pungency levels in FBreeding science · 2025Article
- Histological and Transcriptomic Insights into Rugose Surface Formation in Pepper (Plants (Basel, Switzerland) · 2025Article
- Genome-wide association analysis and linkage mapping decipher the genetic control of primary metabolites and quality traits in Capsicum.The Plant journal : for cell and molecular biology · 2025Article
- A multidisciplinary and integrative review of the structural genome and epigenome of Capsicum L. species.Planta · 2025Review
- Genetic dissection of yield and yield-related traits in mungbean based on QTL meta-analysis.Frontiers in genetics · 2025Article
- QTL mapping and genome-wide association analysis reveal genetic loci and candidate gene for resistance to gray leaf spot in tropical and subtropical maize germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Integrative multi-omics analysis reveals genetic and heterotic contributions to male fertility and yield in potato.Nature communications · 2024Article
- A genome-wide association study reveals molecular mechanism underlying powdery mildew resistance in cucumber.Genome biology · 2024Article
- Genomic structure and marker-trait association for plant and fruit traits in Capsicum chinense and Capsicum baccatum germplasm.BMC research notes · 2024Article
- Insights into the genetic architecture of Phytophthora capsici root rot resistance in chile pepper (Capsicum spp.) from multi-locus genome-wide association study.BMC plant biology · 2024Article
- Genetic characterization of a locus responsible for low pungency using EMS-induced mutants in Capsicum annuum L.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genomic Analysis of Romanian Lycium Genotypes: ExploringInternational journal of molecular sciences · 2024Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsaicinoids are unique compounds produced only in peppers (Capsicum spp.). Several studies using classical quantitative trait loci (QTLs) mapping and genomewide association studies (GWAS) have identified QTLs controlling capsaicinoid content in peppers; however, neither the QTLs common to each population nor the candidate genes underlying them have been identified due to the limitations of each approach used. Here, we performed QTL mapping and GWAS for capsaicinoid content in peppers using two recombinant inbred line (RIL) populations and one GWAS population. Whole-genome resequencing and genotyping by sequencing (GBS) were used to construct high-density single nucleotide polymorphism (SNP) maps. Five QTL regions on chromosomes 1, 2, 3, 4 and 10 were commonly identified in both RIL populations over multiple locations and years. Furthermore, a total of 109 610 SNPs derived from two GBS libraries were used to analyse the GWAS population consisting of 208 C. annuum-clade accessions. A total of 69 QTL regions were identified from the GWAS, 10 of which were co-located with the QTLs identified from the two biparental populations. Within these regions, we were able to identify five candidate genes known to be involved in capsaicinoid biosynthesis. Our results demonstrate that QTL mapping and GBS-GWAS represent a powerful combined approach for the identification of loci controlling complex traits.
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