ArticleVirulence2018
Modulatory upregulation of an insulin peptide gene by different pathogens in C. elegans.
Article in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Pre-cuticle DPY-6 acts as a blueprint for aECM periodic organization inbioRxiv : the preprint server for biology · 2026Article
- Pre-cuticle DPY-6 acts as a blueprint for aECM periodic organization in C. elegans.PLoS genetics · 2026Article
- A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans.PLoS genetics · 2025Article
- The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response.PLoS biology · 2025Article
- A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage inbioRxiv : the preprint server for biology · 2024Article
- Structural and physiological functions ofHeliyon · 2024Review
- Body stiffness is a mechanical property that facilitates contact-mediated mate recognition in Caenorhabditis elegans.Current biology : CB · 2023Article
- Meisosomes, folded membrane microdomains between the apical extracellular matrix and epidermis.eLife · 2023Article
- Article
- Immunological pathogenesis of Bovine E. coli infection in a model of C. elegans.BMC microbiology · 2022Article
- Article
- Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infections.BMC microbiology · 2022Article
- C. elegans: out on an evolutionary limb.Immunogenetics · 2022Review
- Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences.PLoS genetics · 2021Article
- Article
- Increased Pathogenicity of the Nematophagous FungusFrontiers in fungal biology · 2021Article
- Innate immunity in C. elegans.Current topics in developmental biology · 2021Review
- Transcriptome-wide analysis reveals different categories of response to a standardised immune challenge in a wild rodent.Scientific reports · 2020Article
- Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against pathogenic bacteria.PLoS genetics · 2020Article
- Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation.Trends in immunology · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
When an animal is infected, its innate immune response needs to be tightly regulated across tissues and coordinated with other aspects of organismal physiology. Previous studies with Caenorhabditis elegans have demonstrated that insulin-like peptide genes are differentially expressed in response to different pathogens. They represent prime candidates for conveying signals between tissues upon infection. Here, we focused on one such gene, ins-11 and its potential role in mediating cross-tissue regulation of innate immune genes. While diverse bacterial intestinal infections can trigger the up-regulation of ins-11 in the intestine, we show that epidermal infection with the fungus Drechmeria coniospora triggers an upregulation of ins-11 in the epidermis. Using the Shigella virulence factor OpsF, a MAP kinase inhibitor, we found that in both cases, ins-11 expression is controlled cell autonomously by p38 MAPK, but via distinct transcription factors, STA-2/STAT in the epidermis and HLH-30/TFEB in the intestine. We established that ins-11, and the insulin signaling pathway more generally, are not involved in the regulation of antimicrobial peptide gene expression in the epidermis. The up-regulation of ins-11 in the epidermis does, however, affect intestinal gene expression in a complex manner, and has a deleterious effect on longevity. These results support a model in which insulin signaling, via ins-11, contributes to the coordination of the organismal response to infection, influencing the allocation of resources in an infected animal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.