Evidence map›Paper›PMID 29405697›Full record

ArticleACS infectious diseases2018

Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-

Renuka Sriram, Jinny Sun, Javier Villanueva-Meyer, Christopher Mutch, Justin De Los Santos, Jason Peters, David E Korenchan, Kiel Neumann, Mark Van Criekinge, John Kurhanewicz and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. HyperpolarizedMolecules (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. HyperpolarizedMagnetic resonance in medicine · 2022
    Article
  9. Review
  10. Article
  11. HyperpolarizedNMR in biomedicine · 2019
    Article
  12. [ACS infectious diseases · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Renuka SriramDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.ORCID 0000-0003-3505-2479
Jinny SunDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.
Javier Villanueva-MeyerDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.
Christopher MutchDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.
Justin De Los SantosDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.
Jason PetersMicrobiology and Immunology , University of California, San Francisco , 600 16th Street , San Francisco , California 94158 , United States.
David E KorenchanDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.
Kiel NeumannDepartment of Radiology , University of Virginia , 480 Ray C. Hunt Drive , Charlottesville , Virginia 22903 , United States.
Mark Van CriekingeDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.
John KurhanewiczDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.
Oren RosenbergDivision of Infectious Diseases, School of Medicine , University of California, San Francisco , 505 Parnassus Avenue , San Francisco , California 94143 , United States.
David WilsonDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.
Michael A OhligerDepartment of Radiology and Biomedical Imaging , University of California, San Francisco , 1600 Fourth Street , Box 2520, San Francisco , California 94158 , United States.

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Clinical translation of D-amino acid derived PET tracers for imaging spinalinfectionR01EB024014 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OHLIGER, MICHAEL, WILSON, DAVID M · 2017 to 2020
$2.2M
NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB024014NIBIB NIH HHS R01 EB025985
6 · The paper itself

Abstract

The differentiation of bacterial infection from other causes of inflammation is difficult in clinical practice and is critical where patient outcomes rely heavily on early interventions. In addition to physical exam and laboratory markers, several imaging modalities are frequently employed, but these techniques generally target the host immune response, rather than the living microorganisms themselves. Here, we describe a method to detect bacteria-specific metabolism using hyperpolarized (HP)

Indexed as

Energy MetabolismAcetatesBacteriaCarbon-13 Magnetic Resonance SpectroscopyEscherichia coliMetabolic Networks and PathwaysPyruvic AcidAcetatesPyruvic Acidacetatebacterial metabolismdynamic nuclear polarization (DNP)hyperpolarized 13C nuclear magnetic resonance (MR)pyruvate

Identifiers

PMID29405697
PMCPMC6008482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.