ArticlePhysiological reports2018
Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats.
Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system.Nature reviews. Cardiology · 2026Review
- Immunology of Hypertension: Pathophysiological and Therapeutic Aspects.International journal of molecular sciences · 2025Review
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Renal interoception: form, function, and open questions.Current opinion in neurobiology · 2025Review
- Renal interoception in health and disease.Autonomic neuroscience : basic & clinical · 2024Review
- IL-1R Mediated Activation of Renal Sensory Nerves in DOCA-Salt Hypertension.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Sprouting of afferent and efferent inputs to pelvic organs after spinal cord injury.Journal of neuropathology and experimental neurology · 2023Article
- The denervation or activation of renal sympathetic nerve and renal blood flow.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Review
- Renal denervation: basic and clinical evidence.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Article
- Pathophysiology of Hypertension: The Mosaic Theory and Beyond.Circulation research · 2021Review
- Renal sympathetic nerve activity regulates cardiovascular energy expenditure in rats fed high salt.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance.The Canadian journal of cardiology · 2020Review
- Renal sensory nerves increase sympathetic nerve activity and blood pressure in 2-kidney 1-clip hypertensive mice.Journal of neurophysiology · 2019Article
- Device-Based Neuromodulation for Resistant Hypertension Therapy.Circulation research · 2019Review
- Dexamethasone Causes Hypertension in Rats Even Under Chemical Blockade of Peripheral Sympathetic Nerves.Frontiers in neuroscience · 2019Article
- Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats.Physiological reports · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Hypertension is the leading modifiable risk factor for death worldwide, yet the causes remain unclear and treatment remains suboptimal. Catheter-based renal denervation (RDNX) is a promising new treatment for resistant hypertension, but the mechanisms underlying its antihypertensive effect remain unclear. We recently found that RDNX attenuates deoxycorticosterone acetate-salt hypertension and that this is dependent on ablation of afferent renal nerves and is associated with decreased renal inflammation. To determine if this is common to other models of salt-sensitive hypertension, rats underwent complete RDNX (n = 8), selective ablation of afferent renal nerves (n = 8), or sham denervation (n = 8). Mean arterial pressure (MAP) and heart rate were measure by telemetry and rats were housed in metabolic cages for measurement of sodium and water balance. Rats were then subjected to angiotensin II (AngII)-salt hypertension (10 ng/kg/min, intravenous + 4% NaCl diet) for 2 weeks. At the end of the study, renal T-cell infiltration was quantified by flow cytometry. AngII resulted in an increase in MAP of ~50 mmHg in all three groups with no between group differences, and a transient bradycardia that was blunted by selective ablation of afferent renal nerves. Sodium and water balance were unaffected by AngII-salt treatment and similar between groups. Lastly, AngII infusion was not associated with T-cell infiltration into the kidneys, and T-cell counts were unaffected by the denervation procedures. These results suggest that AngII-salt hypertension in the rat is not associated with renal inflammation and that neither afferent nor efferent renal nerves contribute to this model.
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