Evidence map›Paper›PMID 29405568›Full record

ReviewChemphyschem : a European journal of chemical physics and physical chemistry2018

Microfabricated Probes for Studying Brain Chemistry: A Review.

Thitaphat Ngernsutivorakul, Thomas S White, Robert T Kennedy

Open access · greenAbstract readReview
In one paragraph

Review in Chemphyschem : a European journal of chemical physics and physical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 46 citations in OpenAlex.

  1. An opto-microperfusion neural probe for multiplexed detection of optogenetically evoked neurochemical release dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  14. Imaging Guidance for Therapeutic Delivery: The Dawn of Neuroenergetics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thitaphat NgernsutivorakulDepartment of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-3474-3545
Thomas S WhiteMacromolecular Science and Engineering, University of Michigan, 3003E, NCRC Building 28, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Robert T KennedyDepartment of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, MI, 48109, USA.
University of Michigan · US

Funding

In vivo chemical monitoring using capillary separationsR37EB003320 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KENNEDY, ROBERT T · 2008 to 2017
$3.6M
In vivo chemical monitoring using capillary separationsR01EB003320 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KENNEDY, ROBERT T · 2003 to 2020
$2.7M
NIBIB NIH HHS R01 EB003320NIBIB NIH HHS R37 EB003320
6 · The paper itself

Abstract

Probe techniques for monitoring in vivo chemistry (e.g., electrochemical sensors and microdialysis sampling probes) have significantly contributed to a better understanding of neurotransmission in correlation to behaviors and neurological disorders. Microfabrication allows construction of neural probes with high reproducibility, scalability, design flexibility, and multiplexed features. This technology has translated well into fabricating miniaturized neurochemical probes for electrochemical detection and sampling. Microfabricated electrochemical probes provide a better control of spatial resolution with multisite detection on a single compact platform. This development allows the observation of heterogeneity of neurochemical activity precisely within the brain region. Microfabricated sampling probes are starting to emerge that enable chemical measurements at high spatial resolution and potential for reducing tissue damage. Recent advancement in analytical methods also facilitates neurochemical monitoring at high temporal resolution. Furthermore, a positive feature of microfabricated probes is that they can be feasibly built with other sensing and stimulating platforms including optogenetics. Such integrated probes will empower researchers to precisely elucidate brain function and develop novel treatments for neurological disorders.

Indexed as

AnimalsBrainBrain ChemistryElectrochemical TechniquesHumansMicroelectrodesMicrotechnologyelectrochemical sensorsmicrodialysismicrofabricationneural probesneurochemistry

Identifiers

PMID29405568
PMCPMC6996029
OpenAlexW2794215436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.