ReviewInternational journal of clinical practice2018
Introduction and practical approach to exocrine pancreatic insufficiency for the practicing clinician.
Review in International journal of clinical practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Pancreatic Enzyme Replacement Therapy in Pancreatic Exocrine Insufficiency-Real-World's Dosing and Effectiveness: A Systematic Review.Digestive diseases and sciences · 2025Pooled it
- Exocrine Pancreatic Insufficiency After Pancreatectomy for Malignancy: Systematic Review and Optimal Management Recommendations.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Pooled it
- Pancrelipase Improves Symptoms of Exocrine Pancreatic Insufficiency and Health-Related Quality of Life in a Real-World Population of Patients with Chronic Pancreatitis.Digestive diseases and sciences · 2026Observational
- Unique causes of exocrine pancreatic insufficiency: When to consider pancreatic enzyme supplementation: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Review
- Insufficient Data-Nonrecognition of Pancreatic Exocrine Insufficiency After Bariatric Surgery.Digestive diseases and sciences · 2026Article
- Pancreatic exocrine insufficiency.EClinicalMedicine · 2026Review
- Assessment of Pancreatic Exocrine Insufficiency in Patients with Dyspepsia: Clinical Utility of the PEI-Test in Identifying and Monitoring Response to Enzyme Replacement Therapy.Journal of clinical medicine · 2026Article
- Pancreatic Exocrine Insufficiency After Metabolic and Bariatric Surgery.Digestive diseases and sciences · 2026Review
- Antiradical and Antioxidant Activity and Stimulation of Pancreatic Lipase by Extracts Obtained from Saponin-Rich Raw Materials: Experimental and In Silico Study.International journal of molecular sciences · 2025Article
- Developing the EPI Symptom Questionnaire (EPI-SQ): a qualitative study to understand the symptom experience of patients with exocrine pancreatic insufficiency (EPI).Journal of patient-reported outcomes · 2024Article
- AGA-PancreasFest Joint Symposium on Exocrine Pancreatic Insufficiency.Gastro hep advances · 2023Review
- What is the significance of a faecal elastase-1 level between 200 and 500μg/g?Frontline gastroenterology · 2023Article
- Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis.Journal of clinical medicine · 2021Review
- Turkish Gastroenterology Association, Pancreas Study Group, Chronic Pancreatitis Committee Consensus Report.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Article
- Frequency of Appropriate Use of Pancreatic Enzyme Replacement Therapy and Symptomatic Response in Pancreatic Cancer Patients.Pancreas · 2019Article
- Diabetes and Chronic Pancreatitis: Considerations in the Holistic Management of an Often Neglected Disease.Journal of diabetes research · 2019Review
- Standardized clinical criteria and sweat test combined as a tool to diagnose Cystic Fibrosis.Heliyon · 2018Article
- Challenges in the management of pancreatic exocrine insufficiency.World journal of gastrointestinal pharmacology and therapeutics · 2018Article
- Introduction and practical approach to exocrine pancreatic insufficiency for the practicing clinician.International journal of clinical practice · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsIn exocrine pancreatic insufficiency (EPI), the quantity and/or activity of pancreatic digestive enzymes are below the levels required for normal digestion, leading to maldigestion and malabsorption. Diagnosis of EPI is often challenging because the characteristic signs and symptoms overlap with those of other gastrointestinal conditions. Additionally, there is no single convenient, or specific diagnostic test for EPI. The aim of this review is to provide a framework for differential diagnosis of EPI vs other malabsorptive conditions.
methodsThis is a non-systematic narrative review summarising information pertaining to the aetiology, diagnosis and management of EPI.
resultsExocrine pancreatic insufficiency may be caused by pancreatic disorders, including chronic pancreatitis, cystic fibrosis, pancreatic resection and pancreatic cancer. EPI may also result from extra-pancreatic conditions, including coeliac disease, Zollinger-Ellison syndrome and gastric surgery. Timely and accurate diagnosis of EPI is important, as delays in treatment prolong maldigestion and malabsorption, with potentially serious consequences for malnutrition, overall health and quality of life. Symptoms of EPI are non-specific; therefore, a high index of clinical suspicion is required to make a correct diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.