Evidence map›Paper›PMID 29405480›Full record

ReviewThe European journal of neuroscience2019

Diverse actions of the modulatory peptide neurotensin on central synaptic transmission.

Christopher W Tschumi, Michael J Beckstead

Abstract readReview
In one paragraph

Review in The European journal of neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Analysis of the underlying mechanism ofPharmaceutical science advances · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Neurotensin in reward processes.Neuropharmacology · 2020
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher W TschumiAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104-5005, USA.
Michael J BecksteadAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104-5005, USA.ORCID 0000-0002-1574-530X
Oklahoma Medical Research Foundation · US

Funding

The role of dendrodendritic dopamine neurotransmission in methamphetamine abuseR01DA032701 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BECKSTEAD, MICHAEL J · 2013 to 2017
$1.7M
NIDA NIH HHS R01 DA032701NIDA NIH HHS R01 DA32701Oklahoma Center for Adult Stem Cell ResearchPresbyterian Health Foundation
6 · The paper itself

Abstract

Neurotensin (NT) is a 13 amino acid neuropeptide that is expressed throughout the central nervous system and is implicated in the etiology of multiple diseases and disorders. Many primary investigations of NT-induced modulation of neuronal excitability at the level of the synapse have been conducted, but they have not been summarized in review form in nearly 30 years. Therefore, the goal of this review is to discuss the many actions of NT on neuronal excitability across brain regions as well as NT circuit architecture. In the basal ganglia as well as other brain nuclei, NT can act through diverse intracellular signaling cascades to enhance or depress neuronal activity by modulating activity of ion channels, ionotropic and metabotropic neurotransmitter receptors, and presynaptic release of neurotransmitters. Further, NT can produce indirect effects by evoking endocannabinoid release, and recently has itself been identified as a putative retrograde messenger. In the basal ganglia, the diverse actions and circuit architecture of NT signaling allow for input-specific control of reward-related behaviors.

Indexed as

AnimalsBasal GangliaBrainDopaminergic NeuronsEndocannabinoidsNeurotensinPeptidesSignal TransductionSynapsesSynaptic TransmissionEndocannabinoidsNeurotensinPeptidesendocannabinoidsmethamphetamineneuropeptidesubstantia nigraVTA

Identifiers

PMID29405480
PMCPMC6078827
OpenAlexW2793377135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.