Evidence map›Paper›PMID 29405338›Full record

ArticleThe International journal of eating disorders2018

Toward valid and reliable brain imaging results in eating disorders.

Guido K W Frank, Angela Favaro, Rachel Marsh, Stefan Ehrlich, Elizabeth A Lawson

Abstract read
In one paragraph

Article in The International journal of eating disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  20. Trait anxiety is associated with amygdala expectation and caloric taste receipt response across eating disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guido K W FrankDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, Colorado.ORCID 0000-0002-6590-3441
Angela FavaroDepartment of General Psychology, University of Padova, Padova, Italy.ORCID 0000-0002-6540-5194
Rachel MarshDepartment of Psychiatry, The New York State Psychiatric Institute and the College of Physicians and Surgeons at Columbia University, New York, New York.
Stefan EhrlichDivision of Psychological and Social Medicine and Developmental Neuroscience, Technische Universität Dresden, Dresden, Germany.
Elizabeth A LawsonNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Brain Reward Circuits and Computational Modeling in Adolescent Anorexia NervosaR01MH096777 · NIMH · UNIVERSITY OF COLORADO DENVER · PI FRANK, GUIDO KW · 2012 to 2016
$1.5M
Brain Reward-Pathway Function and Neurocomputational Modeling in Anorexia NervosaK23MH080135 · NIMH · UNIVERSITY OF COLORADO DENVER · PI FRANK, GUIDO KW · 2008 to 2012
$840k
NIDDK NIH HHS P30 DK040561NIMH NIH HHS K23 MH080135NIMH NIH HHS R01 MH096777
6 · The paper itself

Abstract

Human brain imaging can help improve our understanding of mechanisms underlying brain function and how they drive behavior in health and disease. Such knowledge may eventually help us to devise better treatments for psychiatric disorders. However, the brain imaging literature in psychiatry and especially eating disorders has been inconsistent, and studies are often difficult to replicate. The extent or severity of extremes of eating and state of illness, which are often associated with differences in, for instance hormonal status, comorbidity, and medication use, commonly differ between studies and likely add to variation across study results. Those effects are in addition to the well-described problems arising from differences in task designs, data quality control procedures, image data preprocessing and analysis or statistical thresholds applied across studies. Which of those factors are most relevant to improve reproducibility is still a question for debate and further research. Here we propose guidelines for brain imaging research in eating disorders to acquire valid results that are more reliable and clinically useful.

Indexed as

Feeding and Eating DisordersFemaleHumansNeuroimagingbrain imagingeating disordersguidelinemethodreliabilityvalidity

Identifiers

PMID29405338
PMCPMC7449370

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.