Evidence map›Paper›PMID 29405165›Full record

ArticleAsian journal of andrology

The expression of the new epididymal luminal protein of PDZ domain containing 1 is decreased in asthenozoospermia.

A-Juan Liang, Gui-Shuan Wang, Ping Ping, Shuang-Gang Hu, Yu Lin, Yi Ma, Zheng-Zheng Duan, Han-Shu Wang, Fei Sun

Open access · goldAbstract read
In one paragraph

Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

A-Juan LiangInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory for Reproductive Medicine, Institute of Embryo-Fetal Original Adult Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Gui-Shuan WangMedical School, Institute of Reproductive Medicine, Nantong University, Nantong 226001, China.
Ping PingInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory for Reproductive Medicine, Institute of Embryo-Fetal Original Adult Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Shuang-Gang HuShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China.
Yu LinInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory for Reproductive Medicine, Institute of Embryo-Fetal Original Adult Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Yi MaShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China.
Zheng-Zheng DuanInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory for Reproductive Medicine, Institute of Embryo-Fetal Original Adult Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Han-Shu WangInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory for Reproductive Medicine, Institute of Embryo-Fetal Original Adult Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Fei SunInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory for Reproductive Medicine, Institute of Embryo-Fetal Original Adult Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Shanghai Jiao Tong University · CNInternational Peace Maternity & Child Health Hospital · CNNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermatozoa are not mature until they transit the epididymis where they acquire motility and the ability to fertilize an egg through sequential modifications. The epididymis has three functional regions, caput, corpus, and cauda, and the luminal proteins of the epididymis play important roles in the above modifications. However, the proteins with differential enrichment between the caput and cauda are still largely unknown. To reveal the functions of the caput and cauda during sperm maturation, luminal proteins from caput and cauda of mice were analyzed by isobaric tag for relative and absolute quantitation (iTRAQ). Overall, 128 differentially enriched proteins were found, of which 46 were caput enriched and 82 were cauda enriched. Bioinformatic analysis showed that lipid metabolism was active in the caput; while anion- and cation-binding activity and phosphorus and organophosphate metabolism were active in the cauda. A new epididymal luminal protein, the caput-enriched PDZ domain containing 1 (Pdzk1), also named Na

Indexed as

Sperm MaturationAdultAnimalsAsthenozoospermiaCarrier ProteinsCase-Control StudiesEpididymisHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceSpermatozoaSperm TailTestisCarrier ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsPDZK1 protein, humanPDZK1 protein, mouseasthenozoospermiaepididymisfertilityPDZ domain containing 1sperm

Identifiers

PMID29405165
PMCPMC5858100
OpenAlexW2789745828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.