Evidence map›Paper›PMID 29405117›Full record

ArticleeLife2018

Hypocretin underlies the evolution of sleep loss in the Mexican cavefish.

James B Jaggard, Bethany A Stahl, Evan Lloyd, David A Prober, Erik R Duboue, Alex C Keene

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
29.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 119 citations in OpenAlex.

  1. Article
  2. Article
  3. Novel mechanisms of chemosensory adaptation to the cave environment.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Postprandial sleep in short-sleeping Mexican cavefish.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Ontogeny and social context regulate the circadian activity patterns of Lake Malawi cichlids.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024
    Article
  12. Review
  13. Phylogenetic conservation of the interdependent homeostatic relationship of sleep regulation and redox metabolism.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024
    Review
  14. Review
  15. Evo-devo applied to sleep research: an approach whose time has come.Sleep advances : a journal of the Sleep Research Society · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

James B JaggardDepartment of Biological Sciences, Florida Atlantic University, Jupiter, United States.ORCID 0000-0003-4091-9946
Bethany A StahlDepartment of Biological Sciences, Florida Atlantic University, Jupiter, United States.ORCID 0000-0001-9218-2996
Evan LloydDepartment of Biological Sciences, Florida Atlantic University, Jupiter, United States.
David A ProberDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-7371-4675
Erik R DuboueDepartment of Embryology, Carnegie Institution for Science, Baltimore, United States.ORCID 0000-0003-3303-5149
Alex C KeeneDepartment of Biological Sciences, Florida Atlantic University, Jupiter, United States.ORCID 0000-0001-6118-5537
Florida Atlantic University · USCalifornia Institute of Technology · USCarnegie Institution for Science · US

Funding

Neuropeptidergic Regulation of Zebrafish SleepR01NS070911 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PROBER, DAVID AARON · 2011 to 2020
$3.5M
Role of Prokineticin 2 in Regulating Sleep in ZebrafishR01NS095824 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PROBER, DAVID AARON · 2017 to 2021
$1.8M
Regulation of Zebrafish Sleep by Neuromedin UR01NS101158 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PROBER, DAVID AARON · 2017 to 2020
$1.4M
Circadian Regulation of Zebrafish Sleep by MelatoninR01NS101665 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PROBER, DAVID AARON · 2017 to 2020
$1.4M
Development of genetic tools for functional analysis of sleep in cavefishR21NS105071 · NINDS · FLORIDA ATLANTIC UNIVERSITY · PI KEENE, ALEX C · 2018 to 2019
$400k
NINDS NIH HHS R01 NS070911NINDS NIH HHS R01 NS095824NINDS NIH HHS R01 NS101158NINDS NIH HHS R01 NS101665NINDS NIH HHS R21 NS105071
6 · The paper itself

Abstract

The duration of sleep varies dramatically between species, yet little is known about the genetic basis or evolutionary factors driving this variation in behavior. The Mexican cavefish,

Indexed as

SleepUp-RegulationAnimalsBiological EvolutionCharacidaeGene Expression ProfilingHypothalamusMexicoOrexinsOrexinscavefishmetabolismneuroscienceOrexinsensory processingsleep

Identifiers

PMID29405117
PMCPMC5800846
OpenAlexW2952378441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.