Evidence map›Paper›PMID 29405108›Full record

ArticleThe American journal of tropical medicine and hygiene2018

Regulatory T-Cell Dynamics in Cutaneous and Mucocutaneous Leishmaniasis due to

Nicolas Barros, Nestor Vasquez, Fernando Woll, Cesar Sanchez, Braulio Valencia, Alejandro Llanos-Cuentas, A Clinton White, Martin Montes

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Nicolas BarrosInstituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.
Nestor VasquezInstituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.
Fernando WollInstituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.
Cesar SanchezInstituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.
Braulio ValenciaInstituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.
Alejandro Llanos-CuentasInstituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.
A Clinton WhiteDivision of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Martin MontesDivision of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Universidad Peruana Cayetano Heredia · PE

Funding

Baylor-Cayetano Heredia Training Program in Global Infectious DiseasesD43TW006569 · FIC · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WHITE, ARTHUR CLINTON · 2003 to 2007
$640k
Regulatory T cells in American Tegumentary LeishmaniasisR01AI075575 · NIAID · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI LLANOS, ALEJANDRO · 2008 to 2011
$318k
FIC NIH HHS D43 TW006569NIAID NIH HHS R01 AI075575
6 · The paper itself

Abstract

To evaluate the dynamics of regulatory T cells (Tregs) during tegumentary leishmaniasis, we assessed peripheral blood and biopsies from 54 patients. Patients with cutaneous leishmaniasis (CL) had a decreased proportion of Tregs in the peripheral blood, but the proportion was higher in the biopsies of lesions. During treatment of CL, circulating Tregs increased reaching normal proportions, whereas antigen-specific interferon-γ responses diminished. By contrast, circulating Tregs from mucosal leishmaniasis patients failed to normalize during treatment. C-C chemokine receptor type 5 was expressed on a large proportion of Tregs at the site of infection. These results demonstrate increased Tregs at the site of infection, possibly homing from the peripheral circulation.

Indexed as

Leishmania braziliensisAdultAgedFemaleHumansInterferon-gammaLeishmaniasis, CutaneousLeishmaniasis, MucocutaneousMaleMiddle AgedReceptors, CCR5T-Lymphocytes, RegulatoryCCR5 protein, humanInterferon-gammaReceptors, CCR5

Identifiers

PMID29405108
PMCPMC5930896
OpenAlexW2789622231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.