Evidence map›Paper›PMID 29405096›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

A role for heat shock factor 1 in hypercapnia-induced inhibition of inflammatory cytokine expression.

Ziyan Lu, S Marina Casalino-Matsuda, Aisha Nair, Anja Buchbinder, G R Scott Budinger, Peter H S Sporn, Khalilah L Gates

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Hypercapnia Effects on Lung Function.Comprehensive Physiology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Therapeutic evaluation of immunomodulators in reducing surgical wound infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  10. Article
  11. Review
  12. Elevated COInterface focus · 2021
    Review
  13. Article
  14. Hypercapnia: An Aggravating Factor in Asthma.Journal of clinical medicine · 2020
    Review
  15. AMP-Activated Protein Kinase (AMPK) at the Crossroads Between COInternational journal of molecular sciences · 2020
    Review
  16. High COAmerican journal of respiratory cell and molecular biology · 2020
    Article
  17. Humidified Warmed COFrontiers in medicine · 2020
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ziyan LuDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
S Marina Casalino-MatsudaDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Aisha NairDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Anja BuchbinderUniversities of Giessen and Marburg Lung Center, Giessen, Germany.
G R Scott BudingerDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Peter H S SpornDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Khalilah L GatesDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Northwestern University · USJesse Brown VA Medical Center · USUniversities of Giessen and Marburg Lung Center · DE

Funding

Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9M
Genes Mediating Innate Immune Suppression by Hypercapnia in Mammals and FliesR01HL107629 · NHLBI · NORTHWESTERN UNIVERSITY · PI BEITEL, GREG J, SPORN, PETER H · 2012 to 2015
$1.5M
Hypercapnia and Suppression of Anti-viral Host DefenseR01HL131745 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SPORN, PETER H · 2017 to 2019
$1.2M
Hypercapnia and neutrophil function in pulmonary host defenseK01HL108860 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GATES, KHALILAH L · 2011 to 2015
$671k
Hypercapnia and Suppression of Anti-viral Host DefenseR56HL131745 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SPORN, PETER H · 2016 to 2016
$391k
NHLBI NIH HHS K01 HL108860NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL107629NHLBI NIH HHS R01 HL131745NHLBI NIH HHS R56 HL131745NIA NIH HHS P01 AG049665
6 · The paper itself

Abstract

Hypercapnia, elevated levels of CO

Indexed as

AnimalsCell LineCells, CulturedHeat Shock Transcription FactorsHypercapniaInterleukinsMacrophagesMiceMice, Inbred C57BLNF-kappa BTumor Necrosis Factor-alphaHeat Shock Transcription FactorsHsf1 protein, mouseInterleukinsNF-kappa BTumor Necrosis Factor-alphabacterial infectionslungmacrophagerodentstress response

Identifiers

PMID29405096
PMCPMC5998969
OpenAlexW2786184285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.