ArticleNeurotoxicity research2018
An Evaluation of Neurotoxicity Following Fluoride Exposure from Gestational Through Adult Ages in Long-Evans Hooded Rats.
Open access · hybridAbstract read
In one paragraph
Article in Neurotoxicity research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Molecular mechanisms underlaying fluoride-induced neurotoxicity: interplay of antioxidants and endoplasmic reticulum stress-mediated apoptotic pathways in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Probing the Biological Plausibility of Fluoride as an Endocrine Disruptor.Birth defects research · 2026Article
- Grape Seed Proanthocyanins Extract Ameliorates the Neurotoxicity Induced by Fluoride Through mTOR/p70s6k Signaling Pathway in Vivo and in Vitro.Cell biochemistry and biophysics · 2026Article
- Fluoride and the brain: A systematic review of neurotoxicity and developmental risks.Genetics and molecular biology · 2026Article
- Updated consumer risk assessment of fluoride in food and drinking water including the contribution from other sources of oral exposure.EFSA journal. European Food Safety Authority · 2025Article
- Testicular protective effects of hesperidin against chemical and biological toxicants.Toxicology research · 2024Review
- The Effect of Prenatal and Neonatal Fluoride Exposure to Morphine-Induced Neuroinflammation.International journal of molecular sciences · 2024Article
- Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.The Science of the total environment · 2023Article
- A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment.Advances in nutrition (Bethesda, Md.) · 2023Article
- Domain-specific effects of prenatal fluoride exposure on child IQ at 4, 5, and 6-12 years in the ELEMENT cohort.Environmental research · 2022Article
- Distribution of Fluoride in Plasma, Brain, and Bones and Associated Oxidative Damage After Induced Chronic Fluorosis in Wistar Rats.Biological trace element research · 2022Article
- Roadbumps at the Crossroads of Integrating Behavioral andFrontiers in toxicology · 2022Review
- Contribution to the ongoing discussion on fluoride toxicity.Archives of toxicology · 2021Review
- Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses.Archives of toxicology · 2020Review
- Developmental fluoride neurotoxicity: an updated review.Environmental health : a global access science source · 2019Review
- Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada.JAMA pediatrics · 2019Article
- Fluoride related changes in behavioral outcomes may relate to increased serotonin.Physiology & behavior · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Christopher A McPhersonNeurotoxicology Group, National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, Mail Drop C1-04, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
Guozhu ZhangSocial & Scientific Systems, Inc, Durham, NC, 27703, USA.
Richard GilliamNeurotoxicology Group, National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, Mail Drop C1-04, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
Sukhdev S BrarCellular & Molecular Pathology Branch, Division of the National Toxicology Program, NIEHS, Research Tringle Park, NC, 27709, USA.
Ralph WilsonCellular & Molecular Pathology Branch, Division of the National Toxicology Program, NIEHS, Research Tringle Park, NC, 27709, USA.
Amy BrixExperimental Pathology Laboratories, Research Triangle Park, NC, USA.
Catherine PicutCharles River Laboratories, Inc, Durham, NC, USA.
G Jean HarryNeurotoxicology Group, National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, Mail Drop C1-04, P.O. Box 12233, Research Triangle Park, NC, 27709, USA. harry@niehs.nih.gov.ORCID http://orcid.org/0000-0002-0829-7318
National Institute of Environmental Health Sciences · USCharles River Laboratories (United States) · USExperimental Pathology Laboratories · USSocial and Scientific Systems (United States) · US
Funding
Environmentally Induced Alterations In Neuron And Glia Development and AgingZIAES021164 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 2009 to 2021
$15.4MNeuroimmunotoxicology: autoimmunity, viral, infectious aZ01ES101623 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 2003 to 2008
$2.8MEnvironment Effects and Development of Neuron and GliaZ01ES021164 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 1997 to 2008
$409k"Mixtures of Xenoestrogens Alter Estradiol-induced Non-Genomic Signaling"F31ES021164 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI VINAS, RENE · 2012 to 2013
$40kIntramural NIH HHS Z01 ES021164Intramural NIH HHS Z01 ES101623NIEHS NIH HHS 1Z01ES101623; ES021164NIEHS NIH HHS F31 ES021164NIEHS NIH HHS HHSN273201500012CNIEHS NIH HHS HHSN273201500012INIEHS NIH HHS HHSN273201600011C
Abstract
At elevated levels, fluoride (F
Indexed as
Environmental ExposurePrenatal Exposure Delayed EffectsAnimalsBehavior, AnimalBrainFemaleFemurFluoridesLearningMaleMemoryMotor ActivityPregnancyProstateRandom AllocationRats, Long-EvansFluoridesThyrotropinThyroxineTriiodothyronineActivityAvoidanceFluorideLearning and memoryNeurodevelopment
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.