ArticleFish physiology and biochemistry2018
Spexin in the half-smooth tongue sole (Cynoglossus semilaevis): molecular cloning, expression profiles, and physiological effects.
Article in Fish physiology and biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Association between spexin and type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Spexin disrupts migrating myoelectric complex in the rat small intestine: The role of galanin-2 and muscarinic receptors.Pflugers Archiv : European journal of physiology · 2026Article
- Spexin-Mediated Dietary Adaptation inAnimals : an open access journal from MDPI · 2025Article
- Spexin and its receptors in the yellowtail kingfish (Seriola lalandi): identification, expression profiles and reproductive function.Fish physiology and biochemistry · 2024Article
- Advances in research on spexin-mediated regulation of reproductive function in vertebrates.Frontiers in endocrinology · 2024Review
- Spexin in the European sea bass, Dicentrarchus labrax: Characterization, brain distribution, and interaction with Gnrh and Gnih neurons.The Journal of comparative neurology · 2023Article
- Spexin mRNA profile and its response to different photoperiods in Chinese Yangzhou geese (Frontiers in veterinary science · 2022Article
- New evidence for SPX2 in regulating the brain-pituitary reproductive axis of half-smooth tongue sole (Frontiers in endocrinology · 2022Article
- Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates.Frontiers in endocrinology · 2022Review
- Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour.Nature reviews. Endocrinology · 2021Review
- Gonadotropin Inhibitory Hormone and Its Receptor: Potential Key to the Integration and Coordination of Metabolic Status and Reproduction.Frontiers in endocrinology · 2021Review
- Mouse Spexin: (I) NMR Solution Structure, Docking Models for Receptor Binding, and Histological Expression at Tissue Level.Frontiers in endocrinology · 2021Article
- Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus.Frontiers in endocrinology · 2021Article
- Identification, tissue distribution, periprandial expression, and anorexigenic effect of spexin in Siberian sturgeon, Acipenser baeri.Fish physiology and biochemistry · 2020Article
- Spexin status in relation to obesity and its related comorbidities: a systematic review.Journal of diabetes and metabolic disorders · 2020Review
- Peripheral Spexin Inhibited Food Intake in Mice.International journal of endocrinology · 2020Article
- Comparative Genomics Studies on theFrontiers in genetics · 2020Article
- Spexin and a Novel Cichlid-Specific Spexin Paralog Both Inhibit FSH and LH Through a Specific Galanin Receptor (Galr2b) in Tilapia.Frontiers in endocrinology · 2020Article
- Evolution of Structural and Functional Diversity of Spexin in Mammalian and Non-mammalian Vertebrate Species.Frontiers in endocrinology · 2019Review
- Emerging Roles of NPQ/Spexin in Physiology and Pathology.Frontiers in pharmacology · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Spexin (SPX), a novel neuropeptide discovered by the bioinformatics approach, has been shown to exert pleiotropic functions in mammals. However, little information regarding the physiological role of SPX is available in teleosts. As a first step, we cloned the spexin gene from a flatfish, the half-smooth tongue sole. The open reading frame (ORF) of tongue sole spexin contained 363 nucleotides encoding a 120 amino acid (aa) preprohormone with a calculated molecular mass and isoelectric point of 14.06 kDa and 5.86, respectively. The tongue sole SPX precursor contained a 27 aa signal peptide and a 14 aa mature peptide flanked by two dibasic protein cleavage sites (RR and GRR). Tissue distribution analysis showed that spexin mRNA could be detected in various tissues, notably in the brain. In addition, fasting stimulated the hypothalamic expression of spexin mRNA. Intraperitoneal injection of SPX increased gnih and gnrh3 mRNA levels in the hypothalamus; however, SPX inhibited the pituitary expression of gh, fshβ, and gthα mRNAs. Overall, our results reveal the existence of a functional SPX in the tongue sole, which could represent an important factor in the neuroendocrine control of flatfish reproduction and growth, and the spexin mRNA expression is regulated by feeding status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.