SynthesisParasitology research2018
Does Dientamoeba fragilis cause diarrhea? A systematic review.
Synthesis in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Treatment outcomes in symptomatic Dientamoeba fragilis infection: a prospective clinical and molecular study.Infection · 2026Observational
- Article
- Associations between Blastocystis spp., Campylobacter spp., Giardia duodenalis and Dientamoeba fragilis using Bayesian priors to account for diagnostic test accuracy.European journal of microbiology & immunology · 2025Article
- Comparative analysis of commercial and "In-House" molecular tests for the detection of intestinal protozoa in stool samples.Parasites & vectors · 2025Article
- Spatiotemporal Analysis of the Distribution of Waterborne Diseases in Children Under 5 Years of Age From 2018 to 2022 in the Lemba Health Zone in Kinshasa, DR Congo: A Retrospective and Observational Analysis.Health science reports · 2025Article
- Observational
- A prospective analysis of clinical and parasitological outcomes after treatment or a wait-and-see approach of Dientamoeba fragilis infection in an adult general practice population.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Observational
- Article
- Investigation of intestinal parasites by conventional and molecular methods in children with gastrointestinal system complaints.Parasitology research · 2023Article
- Interplay between Intestinal Bacterial Communities and Unicellular Parasites in a Morbidly Obese Population: A Neglected Trinomial.Nutrients · 2022Article
- Prevalence and genetic characterization of Dientamoeba fragilis in asymptomatic children attending daycare centers.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
- Dientamoeba fragilis Infection in Patients with Digestive and Non-Digestive Symptoms: A Case-Control Study.The Korean journal of parasitology · 2020Article
- Sympatric western lowland gorillas, central chimpanzees and humans are infected with different trichomonads.Parasitology · 2020Article
- Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment.International journal for parasitology. Drugs and drug resistance · 2019Article
- Two Drinking Water Outbreaks Caused by Wastewater Intrusion Including Sapovirus in Finland.International journal of environmental research and public health · 2019Article
- Comparison of three commercial multiplex PCR assays for the diagnosis of intestinal protozoa.Parasite (Paris, France) · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It remains controversial whether Dientamoeba fragilis is a commensal parasite or a pathogen. The objective of this systematic review was to establish the strength of the evidence that Dientamoeba fragilis would cause diarrhea. A search was performed for studies that reported either the association between D. fragilis detection in stools and diarrhea or diarrhea outcomes with D. fragilis therapy or challenge. Data from seven studies of specific populations reported that 22% had D. fragilis in stools of which only 23% had diarrhea. Eleven studies of stool samples submitted to laboratories reported that 4.3% of individuals had D. fragilis of which 54% had diarrhea. Twelve studies reported that D. fragilis was detected from 1.6% of individuals with diarrhea and 9.6% of diarrheal stools. Five studies analyzed the prevalence of D. fragilis in individuals with and without diarrhea; the two with a statistically significant difference between groups had discordant results. The only cohort study with an appropriate control group reported diarrhea in a higher proportion of children with D. fragilis than in controls. No D. fragilis treatment studies included diarrhea as an outcome. There were only two challenge studies involving one person each. In conclusion, the evidence that D. fragilis would cause diarrhea or that treatment would hasten diarrhea resolution is inconclusive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.