SynthesisCurrent pain and headache reports2018
The Effect of Ketamine Infusion in the Treatment of Complex Regional Pain Syndrome: a Systemic Review and Meta-analysis.
Synthesis in Current pain and headache reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05212571 (Long-term Pain Modulation by Intravenous Esketamine in Complex Regional Pain Syndrome), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term Pain Modulation by Intravenous Esketamine in Complex Regional Pain Syndrome: a Non-inferiority Study
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Pooled it
- Nitrous oxide for the treatment of complex regional pain syndrome: a randomized blinded trial.Regional anesthesia and pain medicine · 2024Trial
- Randomized controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in adults with complex regional pain syndrome.Pain medicine (Malden, Mass.) · 2023Trial
- Efficacy and Tolerability of Oral Compared with Sublingual Ketamine Lozenges as Rescue Analgesics in Adults for Acute Pain: The OSKet Trial.Clinical drug investigation · 2021Trial
- Management of Neuropathic Pain in Complex Regional Pain Syndrome: A Comprehensive Review.Pain practice : the official journal of World Institute of Pain · 2026Review
- Effects of Esketamine Infusion by Patient-Controlled Intravenous Analgesia in Patients With Zoster-Associated Pain: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Long-term relief of CRPS-associated limb dystonia with ketamine infusion.BMJ case reports · 2026Article
- Ketamine-From an Anesthetic to a Psychiatric Drug: Mechanisms of Action, Clinical Applications and Potential Risks.Molecules (Basel, Switzerland) · 2025Review
- 10. Complex regional pain syndrome.Pain practice : the official journal of World Institute of Pain · 2025Review
- The Impact of Ketamine on Outcomes in Acute Pain Management: An Umbrella Review.Journal of clinical medicine · 2024Review
- Spinal cord stimulation for the treatment of complex regional pain syndrome: A systematic review of randomized controlled trials.Interventional pain medicine · 2024Review
- Use of Ketamine in Patients with Multifactorial Neuropathic Pain: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Efficacy and Safety of Pharmacological Treatment in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Low-dose ketamine infusions for chronic pain management: Does this qualify as evidence-based practice?British journal of pain · 2023Article
- The complex regional pain syndrome: Diagnosis and management strategies.Neurosciences (Riyadh, Saudi Arabia) · 2023Review
- Ketamine for Complex Regional Pain Syndrome: A Narrative Review Highlighting Dosing Practices and Treatment Response.Anesthesiology clinics · 2023Review
- Narrative Review: Low-Dose Ketamine for Pain Management.Journal of clinical medicine · 2023Review
- Intermittent versus continuous esketamine infusions for long-term pain modulation in complex regional pain syndrome: protocol of a randomized controlled non-inferiority study (KetCRPS-2).BMC musculoskeletal disorders · 2023Article
- Different Types of Pain in Complex Regional Pain Syndrome Require a Personalized Treatment Strategy.Journal of pain research · 2023Review
- Modern Principles of Diagnosis and Treatment in Complex Regional Pain Syndrome.Deutsches Arzteblatt international · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewComplex regional pain syndrome (CRPS) is a painful debilitating neurological condition that accounts for approximately 1.2% of adult chronic pain population. Ketamine, an NMDA receptor antagonist, is an anesthetic agent that has been used by some pain specialists for CRPS. There is a growing body of clinical evidence to support the use of ketamine in the treatment of neuropathic pain, especially CRPS. This meta-analysis study was aimed to examine the efficacy of ketamine in the treatment of CRPS. RECENT
findingsA search of Embase, Pubmed, Web of Knowledge, Cochrane, Clinical Trial.gov , and FDA.gov between Jan 1, 1950, and August 1, 2017, was conducted to evaluate ketamine infusion therapy in the treatment of CRPS. We selected randomized clinical trials or cohort studies for meta-analyses. I
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.