SynthesisWorld journal of urology2018
Chronic urinary tract infection and bladder carcinoma risk: a meta-analysis of case-control and cohort studies.
Synthesis in World journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Risk of urologic cancers in patients with hospital-diagnosed recurrent cystitis: a nationwide population-based study.British journal of cancer · 2026Article
- Development and validation of artificial intelligence-based model for bladder cancer immunophenotyping using whole slide images.NPJ precision oncology · 2026Article
- More than an infection: the ecological puzzle of recurrent urinary tract infections.Frontiers in cellular and infection microbiology · 2026Review
- Sex disparities in bladder cancer diagnosis: evidence from the UK Biobank.World journal of urology · 2025Article
- Review
- Lead Exposure and Bladder Cancer: Molecular Insights from TCGA RNA-Seq and Toxicogenomic Integration.Cancers · 2025Article
- Distinct microbiome profiles on vaginally inserted polypropylene midurethral mesh slings compared to vaginal, urinary, and skin microbiomes.Applied and environmental microbiology · 2025Article
- Sex differences in bladder cancer: understanding biological and clinical implications.Biology of sex differences · 2025Review
- [Urothelial carcinoma of the upper and lower urinary tract-which risk factors make early detection worthwhile?]Urologie (Heidelberg, Germany) · 2025Review
- Review
- Exploring the DNA Methylation Profile of Genes Associated with Bladder Cancer in Bladder Tissue of Patients with Neurogenic Lower Urinary Tract Dysfunction.International journal of molecular sciences · 2024Article
- Diabetes and the risk of bladder cancer subtypes in men and women: results from the Netherlands Cohort Study.European journal of epidemiology · 2024Article
- Adherence to First-Line Intravesical Bacillus Calmette-Guérin Therapy in the Context of Guideline Recommendations for US Patients With High-Risk Non-muscle Invasive Bladder Cancer.Journal of health economics and outcomes research · 2024Article
- Microbiome in Bladder Cancer: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Article
- Is metabolic syndrome associated with high tumor grade and stage of bladder cancer: a systematic review and meta-analysis.Translational cancer research · 2021Article
- Urinary Microbiome: Yin and Yang of the Urinary Tract.Frontiers in cellular and infection microbiology · 2021Review
- Escherichia coli foster bladder cancer cell line progression via epithelial mesenchymal transition, stemness and metabolic reprogramming.Scientific reports · 2020Article
- Dairy Product Consumption and Bladder Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cohort.Frontiers in nutrition · 2020Article
- Improving the Timely Detection of Bladder and Kidney Cancer in Primary Care.Advances in therapy · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis meta-analysis of published case-control and cohort studies sought to quantify the magnitude and direction of association between chronic UTI (defined as the infection of the urinary tract that either does not respond to treatment or keeps recurring) and risk of bladder carcinoma (BCa) (i.e., including mainly urothelial carcinoma, squamous cell carcinoma or adenocarcinoma).
methodsA literature search was conducted using Medline, Embase, Ovid, Web of Science, Science Direct and Cochrane Library, which was supplemented with manual search of reference lists of the identified articles. Case-control and cohort studies examining UTI as a predictor of BCa risk published through June 2016 were eligible. Using random-effects models, odds ratios (OR) or relative risks (RR) from eligible studies were combined to synthesize summary effect estimates. The included studies were assessed for methodological quality and potential publication bias. Heterogeneity by study characteristics was examined by sub-group and meta-regression analyses.
resultsEighteen case-control and three cohort studies published between 1963 and 2016 were eligible. Random-effects models showed that UTI was significantly associated with an increased BCa risk both in case-control studies (summary OR
conclusionsChronic UTI was significantly and independently associated with an increased BCa risk. However, due to the presence of high between-study heterogeneity and inconsistent patterns of adjusted confounding effects, more data are needed to clarify the role of chronic UTI in causation of BCa and if established, prompt and effective treatment of UTI may minimize a substantial proportion of BCa risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.