ArticleDiabetologia2018
Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.
Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Association of genetic variation with age at diagnosis in type 1 diabetes.BMJ open diabetes research & care · 2026Pooled it
- Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes.International journal of molecular sciences · 2020Pooled it
- Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia.The Journal of clinical investigation · 2021Trial
- Host genetic variation and gut microbiome in pediatric diseases.Chinese medical journal · 2026Review
- Genetic and metabolomic pathways linking frailty, chronic kidney disease, and kidney failure: a Mendelian randomization and multi-omics analysis.Renal failure · 2025Article
- Improving accuracy in genome-wide association studies: a two-step approach for handling below limit of detection biomarker measurements.NAR genomics and bioinformatics · 2025Article
- Genetic Associations With C-peptide Levels Before Type 1 Diabetes Diagnosis in At-risk Relatives.The Journal of clinical endocrinology and metabolism · 2025Article
- Article
- Associations between diabetes-related genetic risk scores and residual beta cell function in type 1 diabetes: the GUTDM1 study.Diabetologia · 2024Article
- The β Cell in Diabetes: Integrating Biomarkers With Functional Measures.Endocrine reviews · 2021Review
- Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.Diabetes · 2021Article
- The Effect of Ethnicity in the Rate of Beta-Cell Functional Loss in the First 3 Years After Type 1 Diabetes Diagnosis.The Journal of clinical endocrinology and metabolism · 2020Article
- DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes.Nature metabolism · 2020Article
- DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes.Clinical epigenetics · 2020Article
- Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.Diabetes care · 2020Article
- gpart: human genome partitioning and visualization of high-density SNP data by identifying haplotype blocks.Bioinformatics (Oxford, England) · 2019Article
- Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes.BMC medicine · 2019Article
- Transcriptome profiling of four candidate milk genes in milk and tissue samples of temperate and tropical cattle.Journal of genetics · 2019Article
- Type 1 diabetes.Lancet (London, England) · 2018Review
- Clinical and research uses of genetic risk scores in type 1 diabetes.Current opinion in genetics & development · 2018Review
Corrections and comments
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Authors and funding
17 authors at 12 institutions in 3 countries.
Funding
Abstract
aims/hypothesisThe aim of this study was to identify genetic variants associated with beta cell function in type 1 diabetes, as measured by serum C-peptide levels, through meta-genome-wide association studies (meta-GWAS).
methodsWe performed a meta-GWAS to combine the results from five studies in type 1 diabetes with cross-sectionally measured stimulated, fasting or random C-peptide levels, including 3479 European participants. The p values across studies were combined, taking into account sample size and direction of effect. We also performed separate meta-GWAS for stimulated (n = 1303), fasting (n = 2019) and random (n = 1497) C-peptide levels.
resultsIn the meta-GWAS for stimulated/fasting/random C-peptide levels, a SNP on chromosome 1, rs559047 (Chr1:238753916, T>A, minor allele frequency [MAF] 0.24-0.26), was associated with C-peptide (p = 4.13 × 10 CONCLUSIONS/
interpretationWe identified a locus on chromosome 1 and multiple variants in the MHC region, at least some of which were distinct from type 1 diabetes risk loci, that were associated with C-peptide, suggesting partly non-overlapping mechanisms for the development and progression of type 1 diabetes. These associations need to be validated in independent populations. Further investigations could provide insights into mechanisms of beta cell loss and opportunities to preserve beta cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.