ArticleExperimental brain research2018
Neural changes associated with cerebellar tDCS studied using MR spectroscopy.
Article in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review.Human brain mapping · 2021Pooled it
- Cerebellar Transcranial Direct Current Stimulation in Children with Developmental Coordination Disorder: A Randomized, Double-Blind, Sham-Controlled Pilot Study.Journal of autism and developmental disorders · 2022Trial
- Long-Term Application of Cerebellar Transcranial Direct Current Stimulation Does Not Improve Motor Learning in Parkinson's Disease.Cerebellum (London, England) · 2022Trial
- Polarity-dependent modulation of sensory circuits by cerebellar tDCS: local and distant effects.Scientific reports · 2026Article
- Polarity-dependent modulation of sensory circuits by cerebellar tDCS: local and distant effects.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar Non-Invasive Brain Stimulation: A Frontier in Chronic Pain Therapy.Journal of personalized medicine · 2024Review
- Article
- Transcranial direct current stimulation to facilitate neurofunctional rehabilitation in children with autism spectrum disorder: a protocol for a randomized, sham-controlled, double-blind clinical trial.Frontiers in neurology · 2023Article
- Prefrontal tDCS is unable to modulate mind wandering propensity or underlying functional or effective brain connectivity.Scientific reports · 2022Article
- tDCS modulates effective connectivity during motor command following; a potential therapeutic target for disorders of consciousness.NeuroImage · 2022Article
- Non-invasive Brain Stimulation of the Cerebellum in Emotion.Advances in experimental medicine and biology · 2022Article
- Pre-movement changes in sensorimotor beta oscillations predict motor adaptation drive.Scientific reports · 2020Article
- Deep Cerebellar Transcranial Direct Current Stimulation of the Dentate Nucleus to Facilitate Standing Balance in Chronic Stroke Survivors-A Pilot Study.Brain sciences · 2020Article
- Direct current stimulation of endothelial monolayers induces a transient and reversible increase in transport due to the electroosmotic effect.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Anodal cerebellar transcranial direct current stimulation (tDCS) is known to enhance motor learning, and therefore, has been suggested to hold promise as a therapeutic intervention. However, the neural mechanisms underpinning the effects of cerebellar tDCS are currently unknown. We investigated the neural changes associated with cerebellar tDCS using magnetic resonance spectroscopy (MRS). 34 healthy participants were divided into two groups which received either concurrent anodal or sham cerebellar tDCS during a visuomotor adaptation task. The anodal group underwent an additional session involving MRS in which the main inhibitory and excitatory neurotransmitters: GABA and glutamate (Glu) were measured pre-, during, and post anodal cerebellar tDCS, but without the behavioural task. We found no significant group-level changes in GABA or glutamate during- or post-tDCS compared to pre-tDCS levels, however, there was large degree of variability across participants. Although cerebellar tDCS did not affect visuomotor adaptation, surprisingly cerebellar tDCS increased motor memory retention with this being strongly correlated with a decrease in cerebellar glutamate levels during tDCS across participants. This work provides novel insights regarding the neural mechanisms which may underlie cerebellar tDCS, but also reveals limitations in the ability to produce robust effects across participants and between studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.