Evidence map›Paper›PMID 29404498›Full record

ArticleHepatology communications2017

Activin A is a prominent autocrine regulator of hepatocyte growth arrest.

Srividyameena Haridoss, Mladen I Yovchev, Hannah Schweizer, Sabreen Megherhi, Maria Beecher, Joseph Locker, Michael Oertel

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Ligand-specific regulation of a binary enhancer code dictating cellular senescence.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  13. The immunological function of CXCR2 in the liver during sepsis.Journal of inflammation (London, England) · 2022
    Review
  14. Article
  15. Review
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Srividyameena HaridossDepartment of Pathology University of Pittsburgh Pittsburgh PA.
Mladen I YovchevDepartment of Pathology University of Pittsburgh Pittsburgh PA.
Hannah SchweizerDepartment of Pathology University of Pittsburgh Pittsburgh PA.
Sabreen MegherhiDepartment of Pathology University of Pittsburgh Pittsburgh PA.
Maria BeecherDepartment of Pathology University of Pittsburgh Pittsburgh PA.
Joseph LockerDepartment of Pathology University of Pittsburgh Pittsburgh PA.
Michael OertelDepartment of Pathology University of Pittsburgh Pittsburgh PA.
University of Pittsburgh · US

Funding

The role of activin A in mediating liver repopulation after cell transplantationR01DK090325 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OERTEL, MICHAEL · 2011 to 2015
$1.5M
NIDDK NIH HHS R01 DK090325
6 · The paper itself

Abstract

Activin A, a multifunctional cytokine, plays an important role in hepatocyte growth suppression and is involved in liver size control. The present study was aimed to determine the cell location of activin A in the normal rat liver microenvironment and the contribution of activin A signaling to the hepatocyte phenotype to obtain insight into molecular mechanisms. Immunohistochemical and

Identifiers

PMID29404498
PMCPMC5721463
OpenAlexW2765224274

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.