Evidence map›Paper›PMID 29404495›Full record

ArticleHepatology communications2017

Nicotinamide N-methyltransferase expression decreases in iron overload, exacerbating toxicity in mouse hepatocytes.

Tiago Koppe, Bonnie Patchen, Aaron Cheng, Manoj Bhasin, Chris Vulpe, Robert E Schwartz, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real, Pavlos Pissios, Paula G Fraenkel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatology communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Tiago KoppeDivision of Hematology/Oncology.
Bonnie PatchenDivision of Hematology/Oncology.
Aaron ChengDivision of Hematology/Oncology.
Manoj BhasinDepartment of Medicine Harvard Medical School Boston MA.
Chris VulpeDepartment of Physiological Sciences University of Florida Gainesville FL.
Robert E SchwartzDivision of Gastroenterology and Hepatology, Weill Cornell Medical School New York NY.
Jose Maria Moreno-NavarreteDepartment of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona Hospital de Girona Dr. Josep Trueta and Universitat de Girona Girona Spain.
Jose Manuel Fernandez-RealDepartment of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona Hospital de Girona Dr. Josep Trueta and Universitat de Girona Girona Spain.
Pavlos PissiosDivision of Endocrinology, Beth Israel Deaconess Medical Center Boston MA.
Paula G FraenkelDivision of Hematology/Oncology.
Cancer Research Institute · USBeth Israel Deaconess Medical Center · USInstitut d'Investigació Biomèdica de Girona · ESCornell University · USHarvard University · USUniversity of Florida · US

Funding

An integrated molecular approach to understand variation in iron metabolismR01GM083198 · NIGMS · UNIVERSITY OF FLORIDA · PI VULPE, CHRISTOPHER D · 2012 to 2015
$2.7M
Modifiers of hepcidin expression as new therapies for iron overloadR01DK085250 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FRAENKEL, PAULA GOODMAN · 2011 to 2015
$1.9M
Modeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cellsR01CA234614 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2019 to 2023
$1.9M
The role of nicotinamide N-methyltransferase in glucose and lipid homeostasisR01DK083694 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PISSIOS, PAVLOS · 2010 to 2014
$1.9M
New Hepatocyte Model Systems to study Hepatitis B Virus InfectionK08DK101754 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2014 to 2018
$781k
Impact of species-specific host responses on restriction of hepatotropic virusesR21AI117213 · NIAID · PRINCETON UNIVERSITY · PI PLOSS, ALEXANDER, SCHWARTZ, ROBERT E · 2015 to 2016
$471k
NCI NIH HHS R01 CA234614NIAID NIH HHS R21 AI117213NIDDK NIH HHS K08 DK101754NIDDK NIH HHS R01 DK083694NIDDK NIH HHS R01 DK085250NIGMS NIH HHS R01 GM083198
6 · The paper itself

Abstract

Iron overload causes the generation of reactive oxygen species that can lead to lasting damage to the liver and other organs. The goal of this study was to identify genes that modify the toxicity of iron overload. We studied the effect of iron overload on the hepatic transcriptional and metabolomic profile in mouse models using a dietary model of iron overload and a genetic model, the hemojuvelin knockout mouse. We then evaluated the correlation of

Identifiers

PMID29404495
PMCPMC5678920
OpenAlexW2754933198

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.